69004-04-2|妥曲珠利砜|Ponazuril|MFCD09263475-范德生物科技公司

妥曲珠利砜

NMR下载 COA and HPLC MSDS下载
names：
Ponazuril
CAS号：
69004-04-2
MDL Number： MFCD09263475
MF(分子式)： C18H14F3N3O6S MW(分子量)： 457.38
EINECS: Reaxys Number:
Pubchem ID:3050408 Brand:BIOFOUNT

妥曲珠利砜(69004-04-2,Ponazuril)是一种抗原生动物产品，可作用于球菌寄生虫。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
HCC340677-10mg	10mg	97%	¥ 665.00	¥ 665.00		4-7周	- +	¥ 0.00

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	妥曲珠利砜(69004-04-2,Ponazuril);帕那珠利;托曲珠利砜;砜妥曲珠利
英文别名	Ponazuril(69004-04-2);Toltrazuril sulfone;Toltrazuril (sulfone);Marquis
CAS号	69004-04-2
SMILES	Cc1cc(ccc1Oc2ccc(cc2)S(=O)(=O)C(F)(F)F)n3c(=O)[nH]c(=O)n(c3=O)C
Inchi	InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
InchiKey	VBUNOIXRZNJNAD-UHFFFAOYSA-N
分子式 Formula	C18H14F3N3O6S
分子量 Molecular Weight	457.38
闪点 FP	Not available
熔点 Melting point	242-244°C
沸点 Boiling point	Not available
Polarizability极化度	39.6±0.5 10-24cm3
密度 Density	1.5±0.1 g/cm3
蒸汽压 Vapor Pressure	Not available
溶解度Solubility	Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
性状	白色至灰白色固体粉末
储藏条件 Storage conditions	存放在阴凉干燥处，短期（数天至数周）在0-4℃，长期（数月至数年）在-20℃。

妥曲珠利砜(69004-04-2,Ponazuril)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Ponazuril(69004-04-2) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:妥曲珠利砜(69004-04-2,Ponazuril),妥曲珠利砜试剂,妥曲珠利砜抑制剂,妥曲珠利砜的纯度,妥曲珠利砜的作用,妥曲珠利砜的用途,妥曲珠利砜的合成,妥曲珠利砜的厂家,妥曲珠利砜的生产,妥曲珠利砜的MSDS,妥曲珠利砜的价格

产品说明	妥曲珠利砜(69004-04-2,Ponazuril)可以作为药物杂质对照品以及生物医药类试剂。
Introduction	Ponazuril(69004-04-2,妥曲珠利砜) can be used as a reference substance for drug impurities and reagents，only for research.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303+H313+H333
安全防护	P264+P280+P305+P351+P338+P337+P313
备注	实验过程中防止吸入、食入，做好安全防护

象形图
GHS危险说明	Aggregated GHS information provided by 24 companies from 1 notifications to the ECHA C&L Inventory. H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P273, P391, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

象形图

GHS危险说明

Aggregated GHS information provided by 24 companies from 1 notifications to the ECHA C&L Inventory.

H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

防范说明代码

P273, P391, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

Ponazuril inhibits the development of Eimeria vermiformis in experimentally infected outbred Swiss mice(Parasitology Research,2004)

Effects of toltrazuril and ponazuril on the fine structure and multiplication of tachyzoites of the NC-1 strain of Neospora caninum (a synonym of Hammondia heydorni) in cell cultures

Safety of 5% Ponazuril (Toltrazuril sulfone) Oral Suspension and Efficacy against Naturally Acquired Cystoisospora ohioensislike Infection in Beagle Puppies

Development of Experimental Cystoisospora canis Infection Models in Beagle Puppies and Efficacy Evaluation of 5?% Ponazuril (Toltrazuril sulfone) Oral Suspension

An explorative study to assess the efficacy of Toltrazuril-sulfone (Ponazuril) in calves experimentally infected with Neospora caninum(Annals of Clinical Microbiology and Antimicrobials,2002)

1.Fast liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the determination of toltrazuril and its metabolites in food.
Martínez-Villalba A1, Moyano E, Martins CP, Galceran MT. Anal Bioanal Chem. 2010 Aug;397(7):2893-901.
In this work a fast liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method was developed for the analysis of toltrazuril, a coccidiostatic drug, and its metabolites in meat food products. The applicability of atmospheric pressure chemical ionization (APCI) and heated electrospray ionization in both positive and negative modes was studied. APCI in negative mode provided the best results and the base peak originated from the loss of CF(3) (toltrazuril and toltrazuril sulfone) and CHF(3)* (toltrazuril sulfoxide) was used as the precursor ion in MS/MS. A fast LC separation on a C(18) Fused-Core column was used together with the APCI-MS/MS method developed using enhanced mass resolution mode (highly selective selected reaction monitoring, H-SRM) to improve the sensitivity and selectivity for the analysis of these compounds in food samples. A simple sample treatment based on an extraction with acetonitrile and a cleanup with a C(18) cartridge was used.

2.Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits.
Liu C1, Wang SJ, Zhang Q, Shao YX. Exp Anim. 2015;64(1):73-9. doi: 10.1538/expanim.14-0064. Epub 2014 Oct 16.
In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppm), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory.

3.Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril<
Lim JH1, Kim MS, Hwang YH, Song IB, Park BK, Yun HI. J Vet Med Sci. 2010 Aug;72(8):1085-7. Epub 2010 Mar 24.
Toltrazuril (TZR) is a triazine-based antiprotozoal agent. Following a single oral administration of TZR at 10 and 20 mg/kg to male pigs, the mean TZR concentration in plasma peaked at 4.24 and 8.18 microg/ml at 15.0 and 12.0 hr post-dose, respectively. TZR absorbed was rapidly converted to the short-lived intermediary metabolite toltrazuril sulfoxide (TZR-SO), and then metabolized to the reactive toltrazuril sulfone (TZR-SO2). TZR-SO2 was actually more slowly eliminated, with average half-lives of 231 and 245 hr, compared with TZR (48.7 and 68.9 hr) or TZR-SO (51.9 and 53.2 hr) in the 10 and 20 mg/kg groups, respectively. This study demonstrates that TZR metabolizes to TZR-SO2 having a long-terminal half-life, enabling the persistent clinical efficacy in the treatment of I. suis infection. In contrast, special consideration should be given to the residual of TZR-SO2.

4.Development of an analytical methodology for the determination of the antiparasitic drug toltrazuril and its two metabolites in surface water, soil and animal manure.
Olsen J1, Björklund E, Krogh KA, Hansen M. Anal Chim Acta. 2012 Nov 28;755:69-76. doi: 10.1016/j.aca.2012.10.015. Epub 2012 Oct 15.
This paper presents the development, optimization and validation of a LC-MS/MS methodology to determine the antiparasitic veterinary drug toltrazuril and its two main metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in environmental surface water, soil and animal manure. Using solid phase extraction and selective pressurized liquid extraction with integrated clean-up, the analytical method allows for the determination of these compounds down to 0.06-0.13 ng L(-1) in water, 0.01-0.03 ng g(-1)dw in soil and 0.22-0.51 ng g(-1) dw in manure. The deuterated analog of toltrazuril was used as internal standard, and ensured method accuracy in the range 96-123% for water and 77-110% for soil samples. The developed method can also be applied to simultaneously determine steroid hormones in the solid samples. The antiparasitic drug and its metabolites were found in manure and soil up to 114 and 335 pg g(-1) dw, respectively. Little is known regarding the environmental fate and effects of these compounds; consequently more research is urgently needed.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开