帕珠沙星

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帕珠沙星,Pazufloxacin(CAS:127045-41-4)毒理性质：

生物	测试类型	路线	剂量	影响	参考
rat	LD	oral	>5 gm/kg (5000 mg/kg)		Chemotherapy, 43(Suppl
rat	LD	subcutaneous	>5 gm/kg (5000 mg/kg)	SKIN AND APPENDAGES (SKIN): DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
rat	LD50	intravenous	341 mg/kg (341 mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
mouse	LD	oral	>5 gm/kg (5000 mg/kg)		Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
mouse	LD50	intravenous	783 mg/kg (783 mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; LUNGS, THORAX, OR RESPIRATION: DYSPNEA; SKIN AND APPENDAGES (SKIN): DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
dog	LD	oral	>2 gm/kg (2000 mg/kg)		Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
dog	LDLo	intravenous	400 mg/kg (400 mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; GASTROINTESTINAL: NAUSEA OR VOMITING	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]

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Pazufloxacin 功能研究：
Pazufloxacin，T-3761在小鼠中对革兰氏阳性和革兰氏阴性细菌（包括对喹诺酮耐药的粘质沙雷氏菌和铜绿假单胞菌）的全身，肺和泌尿道感染表现出良好的功效。T-3761在小鼠中对大多数感染模型的体内活性与氧氟沙星，环丙沙星，诺氟沙星和托氟沙星的体内活性相当或更高。T-3761对小鼠革兰氏阳性细菌的全身和肺部感染的活性低于托沙沙星，但对耐甲氧西林的金黄色葡萄球菌的感染却没有活性[1]。T-3761具有广泛的活性，并且对革兰氏阳性和阴性细菌具有有效的活性。T-3761对90％的对甲氧西林敏感的金黄色葡萄球菌，对甲氧西林敏感.

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帕珠沙星,Pazufloxacin(CAS:127045-41-4)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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