123286-00-0|Vinfosiltine|Vinfosiltine|-范德生物科技公司

Vinfosiltine

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names：
Vinfosiltine
CAS号：
123286-00-0
MDL Number：
MF(分子式)： C51H72N5O10P MW(分子量)： 946.13
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl (5S,7R,9S)-9-((3aR,3a1R,4R,5S,5aR,10bR)-5-(((S)-1-(diethoxyphosphoryl)-2-methylpropyl)carbamoyl)-3a-ethyl-4,5-dihydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl)-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indole-9-carboxylate
英文别名	Vinfosiltine; S12363; S 12363; S-12363;
CAS号	123286-00-0
SMILES	O=C([C@]1(C2=CC3=C(N(C)[C@@]4([H])[C@@](O)(C(N[C@@H](P(OCC)(OCC)=O)C(C)C)=O)[C@H](O)[C@@]5(CC)[C@@]6([H])[C@]43CCN6CC=C5)C=C2OC)C[C@]7([H])C[C@@](O)(CC)CN(C7)CCC8=C1NC9=C8C=CC=C9)OC
Inchi	InChI=1S/C51H72N5O10P/c1-10-47(60)27-32-28-50(46(59)64-9,40-34(19-23-55(29-32)30-47)33-17-14-15-18-37(33)52-40)36-25-35-38(26-39(36)63-8)54(7)43-49(35)21-24-56-22-16-20-48(11-2,42(49)56)44(57)51(43,61)45(58)53-41(31(5)6)67(62,65-12-3)66-13-4/h14-18,20,25-26,31-32,41-44,52,57,60-61H,10-13,19,21-24,27-30H2,1-9H3,(H,53,58)/t32-,41-,42-,43+,44+,47-,48+,49+,50-,51-/m0/s1
InchiKey	BOELCLFVOBIXIF-MAKKXPIGSA-N
分子式 Formula	C51H72N5O10P
分子量 Molecular Weight	946.13
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Vinfosiltine(CAS:123286-00-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Vinfosiltine is an antineoplastic agent which belongs to the vinca alkaloid group incorporating an amino-phosphonate.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Pierré A, Kraus-Berthier L, Atassi G, Cros S, Poupon MF, Lavielle G, Berlion M, Bizzari JP. Preclinical antitumor activity of a new Vinca alkaloid derivative, S 12363. Cancer Res. 1991 May 1;51(9):2312-8. PubMed PMID: 2015595.

[2]Wright M, Garès M, Verdier-Pinard P, Moisand A, Berlion M, Legrand JJ, Bizzari JP. Differential in vitro action of S-12363, a new vinblastine derivative, and of its epimer on microtubule proteins. Cancer Chemother Pharmacol. 1991;28(6):434-40. PubMed PMID: 1934248.

[3] Berlion M, Arvelo F, Leonce S, Bourgeois Y, Rigaudy P, Bizzari JP, Poupon MF. Antitumor activity of the new vinca-alkaloid S 12363 alone or in combination with verapamil on a human multidrug resistant renal carcinoma xenograft. In Vivo. 1993 Sep-Oct;7(5):399-405. PubMed PMID: 7906553.

[4] Lelievre E, Guillaudeux J, Cardona H, Bourguignat A, Lokiec F, Solere P, Lucas C, Sauveur C. Human pharmacokinetics of a new Vinca alkaloid S 12363 with use of a monoclonal antibody-based radio- or enzyme immunoassay. Cancer Res. 1993 Aug 1;53(15):3536-40. PubMed PMID: 8339259.

[5] Atassi G, Berlion M, el Oche Y, Bizzari JP. Characterization of the pharmacological antitumor effects of S 12363, a new vinca alkaloid. Anticancer Res. 1991 Mar-Apr;11(2):975-80. PubMed PMID: 2064354.

6: Fischel JL, Berlion M, Formento P, Bizzari JP, Milano G. Evaluation of the time-schedule dependency for the cytotoxic activity of the new vinca alkaloid derivative, S 12363 (vinfosiltine). Eur J Cancer. 1993;29A(13):1890-4. PubMed PMID: 8260248.7: Gordon BH, Bakes DM, Bennett P, LeBras B, Walther B, Lucas C, Marc S, Gouyette A. Methods for the analysis of the new vinca alkaloid derivative, S 12363, in plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):163-71. PubMed PMID: 7952064.8: Pierré A, Lavielle G, Hautefaye P, Seurre G, Leonce S, Saint-Dizier D, Boutin JA, Cudennec CA. Pharmacological properties of a new alpha-aminophosphonic acid derivative of vinblastine. Anticancer Res. 1990 Jan-Feb;10(1):139-44. PubMed PMID: 2334119.9: Pierré A, Pérez V, Léonce S, Boutin JA, Saint-Dizier D, Hautefaye P, Lavielle G, Atassi G. Relationship between the cellular accumulation and the cytotoxicity of S12363, a new Vinca alkaloid derivative. Cancer Chemother Pharmacol. 1992;29(5):367-74. PubMed PMID: 1551175.10: Budman DR. New vinca alkaloids and related compounds. Semin Oncol. 1992 Dec;19(6):639-45. Review. PubMed PMID: 1462165.1

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