6138-79-0|Triprolidine HCl|2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride|-范德生物科技公司

Triprolidine HCl

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names：
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride
CAS号：
6138-79-0
MDL Number：
MF(分子式)： C19H23ClN2 MW(分子量)： 314.857
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride
英文别名	Triprolidine HCl; Actidilat; Pro-Actidil; Pro-Entra; Venen; Entra; Actidilon.
CAS号	6138-79-0
SMILES	CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl
Inchi	InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InchiKey	WYUYEJNGHIOFOC-NWBUNABESA-N
分子式 Formula	C19H23ClN2
分子量 Molecular Weight	314.857
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Triprolidine HCl(CAS:6138-79-0 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many antihistamines, the most common side effect is drowsiness. Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15–30 minutes. .
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Xuan X, Huang L, Pan X, Li N. [Simultaneous determination of five cold medicine ingredients in paracetamol triprolidine hydrochloride and pseudoephedrine hydrochloride tablets by pH/organic solvent double-gradient high performance liquid chromatography]. Se Pu. 2013 Feb;31(2):133-8. Chinese. PubMed PMID: 23697177.

[2]Dev R, Kumar A, Pathak K. Solubility-modulated asymmetric membrane tablets of triprolidine hydrochloride: statistical optimization and evaluation. AAPS PharmSciTech. 2012 Mar;13(1):174-83. doi: 10.1208/s12249-011-9738-3. Epub 2011 Dec 20. PubMed PMID: 22183255; PubMed Central PMCID: PMC3299447.

[3] Sandhya B, Hegde AH, Kalanur SS, Katrahalli U, Seetharamappa J. Interaction of triprolidine hydrochloride with serum albumins: thermodynamic and binding characteristics, and influence of site probes. J Pharm Biomed Anal. 2011 Apr 5;54(5):1180-6. doi: 10.1016/j.jpba.2010.12.012. Epub 2010 Dec 16. PubMed PMID: 21215548.

[4] Manassra A, Khamis M, El-Dakiky M, Abdel-Qader Z, Al-Rimawi F. Simultaneous HPLC analysis of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid dosage forms. J Pharm Biomed Anal. 2010 Mar 11;51(4):991-3. doi: 10.1016/j.jpba.2009.10.024. Epub 2009 Nov 10. PubMed PMID: 19954915.

[5] Shakya AK, Arafat TA, Abuawwad AN, Melhim M, Al-Ghani J, Yacoub MJ. Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 15;877(32):4071-8. doi: 10.1016/j.jchromb.2009.10.021. Epub 2009 Oct 31. PubMed PMID: 19926351.

6: Kandimalla KK, Donovan MD. Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. Int J Pharm. 2005 Sep 30;302(1-2):133-44. PubMed PMID: 16105724.7: Shin SC, Choi JS. Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats. Eur J Pharm Biopharm. 2005 Sep;61(1-2):14-9. PubMed PMID: 16005195.8: Zayed SI, Habib IH. Adsorptive stripping voltammetric determination of triprolidine hydrochloride in pharmaceutical tablets. Farmaco. 2005 Jun-Jul;60(6-7):621-5. PubMed PMID: 15950226.9: Shin SC, Choi JS. Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats. Arch Pharm Res. 2005 Jan;28(1):111-4. PubMed PMID: 15742818.10: Zayed SI. New plastic membrane and carbon paste ion selective electrodes for the determination of triprolidine. Anal Sci. 2004 Jul;20(7):1043-8. PubMed PMID: 15293399.1

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