156215-70-2|Sinafloxacin Mesylate|7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (11)|-范德生物科技公司

Sinafloxacin Mesylate

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names：
7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (11)
CAS号：
156215-70-2
MDL Number：
MF(分子式)： C21H26FN3O7S MW(分子量)： 483.5114
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (11)
英文别名	Sinafloxacin Mesylate
CAS号	156215-70-2
SMILES	NC(C1)C2(CC2)CN1C3=C(F)C=C4C(N(C5CC5)C=C(C(O)=O)C4=O)=C3OC.CS(=O)(O)=O
Inchi	InChI=1S/C20H22FN3O4.CH4O3S/c1-28-18-15-11(17(25)12(19(26)27)7-24(15)10-2-3-10)6-13(21)16(18)23-8-14(22)20(9-23)4-5-20;1-5(2,3)4/h6-7,10,14H,2-5,8-9,22H2,1H3,(H,26,27);1H3,(H,2,3,4)
InchiKey	XIBUUAQDLNNKBG-UHFFFAOYSA-N
分子式 Formula	C21H26FN3O7S
分子量 Molecular Weight	483.5114
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sinafloxacin Mesylate(CAS:156215-70-2 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sinafloxacin Mesylate is a quinolone antibiotic potentially for the treatment of bacterial infections. There is a strong interaction between sinafloxacin and BSA. From thermodynamic coordination it can be judged that the binding force between sinafloxacin and BSA is mainly electro-static force. The effect of sinafloxacin on the conformation of BSA was analyzed by synchronous fluorescence spectrometry and three-dimensional fluorescence spectrometry. The emission maximum of tyrosine residues does not show a significant shift, while the small blue shift of tryptophan residues indicates that the hydrophobicity of microenvironment was increased. In addition, in the plasma, there are some metal ions, which can participate in many important vital actions and affect the reactions of the drugs with the serum albumins.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Fei Y, Lu GC, Fan GR, Qi YP, Wu HL, Wu YT. [Studies on interaction of sinafloxacin with bovine serum albumin and effect of the coexistent metal ions on the reaction]. Guang Pu Xue Yu Guang Pu Fen Xi. 2008 Nov;28(11):2609-14. Chinese. PubMed PMID: 19271501.

[2]Fei Y, Lu G, Fan G, Wu Y. Spectroscopic studies on the binding of a new quinolone antibacterial agent: sinafloxacin to DNA. Anal Sci. 2009 Nov;25(11):1333-8. PubMed PMID: 19907091.

[3] Wang S, Wen J, Cui L, Zhang X, Wei H, Xie R, Feng B, Wu Y, Fan G. Optimization and validation of a high performance liquid chromatography method for rapid determination of sinafloxacin, a novel fluoroquinolone in rat plasma using a fused-core C(18)-silica column. J Pharm Biomed Anal. 2010 Mar 11;51(4):889-93. doi: 10.1016/j.jpba.2009.09.046. PubMed PMID: 19896316.

[4] Lu GC, She JH, Jiang H, Li ZY, Yuan BJ. Sixty-day repeated dose toxicity of sinafloxacin in rats and dogs. Food Chem Toxicol. 2008 Feb;46(2):575-80. PubMed PMID: 17942207.

[5] Lin XC, Yan J, Guo LQ, Xie ZH. [Determination of protein by synchronous fluorometric method with a new indole homodimeric cyanine as fluorescence probe]. Guang Pu Xue Yu Guang Pu Fen Xi. 2008 Nov;28(11):2615-8. Chinese. PubMed PMID: 19271502.

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