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Ro-23-9424
- names：
Ro-23-9424
- CAS号：
115622-58-7
MDL Number： - MF(分子式)： C31H31F3N8O8S2 MW(分子量)： 764.75
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|
| 中文别名 | 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((((6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinyl)carbonyl)oxy)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))- |
| 英文别名 | Ro-23-9424; Ro 239424; Ro23-9424. |
| CAS号 | 115622-58-7 |
| SMILES | CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C3=CN(CCF)c4c(F)c(N5CCN(C)CC5)c(F)cc4C3=O)\c6csc(N)n6 |
| Inchi | InChI=1S/C31H31F3N8O8S2/c1-39-5-7-40(8-6-39)24-17(33)9-15-23(19(24)34)41(4-3-32)10-16(25(15)43)30(48)50-11-14-12-51-28-21(27(45)42(28)22(14)29(46)47)37-26(44)20(38-49-2)18-13-52-31(35)36-18/h9-10,13,21,28H,3-8,11-12H2,1-2H3,(H2,35,36)(H,37,44)(H,46,47)/b38-20-/t21-,28-/m1/s1 |
| InchiKey | IKYGJSBKPPIKJK-JDKVAZDPSA-N |
| 分子式 Formula | C31H31F3N8O8S2 |
| 分子量 Molecular Weight | 764.75 |
| 闪点 FP | |
| 熔点 Melting point | |
| 沸点 Boiling point | |
| Polarizability极化度 | |
| 密度 Density | |
| 蒸汽压 Vapor Pressure | |
| 溶解度Solubility | |
| 性状 | Solid powder |
| 储藏条件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 产品说明 | Ro-23-9424(CAS:115622-58-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 |
| Introduction | Ro-23-9424 is a dual-action cephalosporin with an aminothiazolylmethoxyimino-type side chain at the 7 position and fleroxacin esterified at the 3' position. Ro-23-9424 is a new compound has broad and potent antibacterial activity in vitro and in vivo, reflecting contributions from both the beta-lactam moiety and the quinolone moiety. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Matera G, Berlinghieri MC, Foti F, Barreca GS, Focà A. Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes. J Antimicrob Chemother. 1996 Nov;38(5):799-807. PubMed PMID: 8961049. |
| [2]Chapman JS, Bertasso A, Cummings LM, Georgopapadakou NH. Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli. Antimicrob Agents Chemother. 1995 Feb;39(2):564-6. PubMed PMID: 7726536; PubMed Central PMCID: PMC162583. |
| [3] Qadri SM, Ueno Y, Ayub A. Anti-Brucella activity of Ro 23-9424, a dual-action antibacterial. Chemotherapy. 1993 Nov-Dec;39(6):386-9. PubMed PMID: 8222864. |
| [4] Szuna AJ, Blain RW. Determination of a new antibacterial agent (Ro 23-9424) by multidimensional high-performance liquid chromatography with ultraviolet detection and direct plasma injection. J Chromatogr. 1993 Oct 29;620(2):211-6. PubMed PMID: 8300788. |
| [5] Qadri SM, Ueno Y, Saldin H, Cunha BA. In vitro activity of Ro 23-9424, a dual-acting cephalosporin-quinolone antimicrobial agent. J Clin Pharmacol. 1993 Oct;33(10):923-8. PubMed PMID: 8227462. |
6: Spangler SK, Jacobs MR, Pankuch GA, Appelbaum PC. Susceptibility of 170 penicillin-susceptible and penicillin-resistant pneumococci to six oral cephalosporins, four quinolones, desacetylcefotaxime, Ro 23-9424 and RP 67829. J Antimicrob Chemother. 1993 Feb;31(2):273-80. PubMed PMID: 8463172.7: Pfaller MA, Barry AL, Fuchs PC. RO 23-9424, a new cephalosporin 3'-quinolone: in-vitro antimicrobial activity and tentative disc diffusion interpretive criteria. J Antimicrob Chemother. 1993 Jan;31(1):81-8. PubMed PMID: 8444677.8: Edelstein PH, Edelstein MA. In vitro activity of Ro 23-9424 against clinical isolates of Legionella species. Antimicrob Agents Chemother. 1992 Nov;36(11):2559-61. PubMed PMID: 1489206; PubMed Central PMCID: PMC284376.9: Rolston KV, Nguyen HT, Ho DH, LeBlanc B, Bodey GP. In vitro activity of Ro 23-9424, a dual-action antibacterial agent, against bacterial isolates from cancer patients compared with those of other agents. Antimicrob Agents Chemother. 1992 Apr;36(4):879-82. PubMed PMID: 1503453; PubMed Central PMCID: PMC189479.10: Pace J, Bertasso A, Georgopapadakou NH. Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424. Antimicrob Agents Chemother. 1991 May;35(5):910-5. PubMed PMID: 1649574; PubMed Central PMCID: PMC245128.1
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