179474-80-7|Prucalopride hydrochloride|4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride|-范德生物科技公司

Prucalopride hydrochloride

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names：
4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride
CAS号：
179474-80-7
MDL Number：
MF(分子式)： C18H27Cl2N3O3 MW(分子量)： 404.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride
英文别名	R-108512; R 108512; R108512; R 093877; R-093877; R093877; R 93877; R-93877; R93877; Prucalopride hydrochloride; Prucalopride HCl; Motegrity; Resolor; Resotran;
CAS号	179474-80-7
Inchi	InChI=1S/C18H26ClN3O3.ClH/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;/h11-12H,2-10,20H2,1H3,(H,21,23);1H
InchiKey	KKMOQGWTJRGLNN-UHFFFAOYSA-N
分子式 Formula	C18H27Cl2N3O3
分子量 Molecular Weight	404.33
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Prucalopride hydrochloride(CAS:179474-80-7 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Prucalopride hydrochloride is a selective 5-HT4 agonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Available from http://www.ncbi.nlm.nih.gov/books/NBK548650/ PubMed PMID: 31643961.

[2]Tameez Ud Din A, Khan AH, Bajwa H, Maqsood MH, Malik MN. Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation. Cureus. 2019 Apr 4;11(4):e4382. doi: 10.7759/cureus.4382. Review. PubMed PMID: 31218146; PubMed Central PMCID: PMC6553670.

[3] Vijayvargiya P, Camilleri M. Use of prucalopride in adults with chronic idiopathic constipation. Expert Rev Clin Pharmacol. 2019 Jul;12(7):579-589. doi: 10.1080/17512433.2019.1620104. Epub 2019 May 23. Review. PubMed PMID: 31096799.

[4] Bassotti G, Usai Satta P, Bellini M. Prucalopride for the treatment of constipation: a view from 2015 and beyond. Expert Rev Gastroenterol Hepatol. 2019 Mar;13(3):257-262. doi: 10.1080/17474124.2019.1568238. Epub 2019 Jan 23. Review. PubMed PMID: 30791758.

[5] Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK536695/ PubMed PMID: 30694627.

6: Ho C, Severn M. Prucalopride for Gastrointestinal Motility Disorders: A Review of Clinical Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Dec 6. Available from http://www.ncbi.nlm.nih.gov/books/NBK526294/ PubMed PMID: 30260606.7: Omer A, Quigley EMM. An update on prucalopride in the treatment of chronic constipation. Therap Adv Gastroenterol. 2017 Nov;10(11):877-887. doi: 10.1177/1756283X17734809. Epub 2017 Oct 16. Review. PubMed PMID: 29147138; PubMed Central PMCID: PMC5673021.8: Smart CJ, Malik KI. Prucalopride for the treatment of ileus. Expert Opin Investig Drugs. 2017 Apr;26(4):489-493. doi: 10.1080/13543784.2017.1301427. Epub 2017 Mar 10. Review. PubMed PMID: 28277883.9: Shin A. Patient considerations in the management of chronic constipation: focus on prucalopride. Patient Prefer Adherence. 2016 Jul 28;10:1373-84. doi: 10.2147/PPA.S92550. eCollection 2016. Review. PubMed PMID: 27528801; PubMed Central PMCID: PMC4970632.10: Bellini M, Gambaccini D, Bassotti G. Prucalopride: For functional constipation only? Tech Coloproctol. 2016 Jul;20(7):433-6. doi: 10.1007/s10151-016-1477-8. Epub 2016 May 12. Review. PubMed PMID: 27174045.1

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