122021-74-3|Lithospermate B|Lithospermate B|-范德生物科技公司

Lithospermate B

NMR下载 COA and HPLC MSDS下载
names：
Lithospermate B
CAS号：
122021-74-3
MDL Number：
MF(分子式)： C36H28MgO16 MW(分子量)： 740.9
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Magnesium, ((1R)-1-(carboxy-kappaO)-2-(3,4-dihydroxyphenyl)ethyl (2S,3S)-4-((1E)-3-((1R)-1-(carboxy-kappaO)-2-(3,4-dihydroxyphenyl)ethoxy)-3-(oxo-kappaO)-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylato(2-)-kappaO3')-, (T-4)-
英文别名	Lithospermate B; Magnesium lithospermate B; Magnesium tanshinoate B; Lithospermic acid B Mg complex;
CAS号	122021-74-3
SMILES	Oc1c(O)cc(C[C@H]2OC3=O[Mg+2]4([O-]C2=O)O=C([C@@H]5[C@@H](c6cc(O)c(O)cc6)Oc7c5c(/C=C\3)ccc7O)O[C@@H](C([O-]4)=O)Cc8cc(O)c(O)cc8)cc1
Inchi	InChI=1S/C36H30O16.Mg/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17;/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48);/q;+2/p-2/b10-5-;/t27-,28-,31+,32-;/m1./s1
InchiKey	ANUBYMNVOPVATP-RBRJVDKYSA-L
分子式 Formula	C36H28MgO16
分子量 Molecular Weight	740.9
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lithospermate B(CAS:122021-74-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lithospermate B is a major biologically active component of dan shen; improves renal failure.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jiang F, Mao Y, Liu H, Xu P, Zhang L, Qian X, Sun X. Magnesium Lithospermate B Protects Neurons Against Amyloid β (1-42)-Induced Neurotoxicity Through the NF-κB Pathway. Neurochem Res. 2015 Sep;40(9):1954-65. doi: 10.1007/s11064-015-1691-[1]Epub 2015 Aug 19. PubMed PMID: 26285901.

[2]Jiang X, Jiang Y, Sun D, Rong L. Protective effect of magnesium lithospermate B against dextran sodiumsulfate induced ulcerative colitis in mice. Environ Toxicol Pharmacol. 2013 Jul;36(1):97-102. doi: 10.1016/j.etap.2013.03.010. Epub 2013 Mar 22. PubMed PMID: 23603461.

[3] Quan W, Wei G, Zhou D, Zhu Y, Guo C, Wang Y, Weng Y, Xi M, Wen A. Magnesium lithospermate B reduces myocardial ischemia/reperfusion injury in rats via regulating the inflammation response. Pharm Biol. 2013 Nov;51(11):1355-62. doi: 10.3109/13880209.2013.791324. Epub 2013 Jul 18. PubMed PMID: 23863120.

[4] Song S, Liu W, Liu F, Wang Z, Ding G, Guo W, Fu Z. Magnesium lithospermate B reduces inflammatory response in a mouse model of hepatic ischemia-reperfusion injury. Cell Biochem Biophys. 2014 Jun;69(2):347-55. doi: 10.1007/s12013-013-9806-2. PubMed PMID: 24385154.

[5] Quan W, Liu F, Zhang Y, Xie C, Wu B, Yin J, Wang L, Zhang W, Zhang X, Wu Q. Antidepressant-like effects of magnesium lithospermate B in a rat model of chronic unpredictable stress. Pharm Biol. 2015 Aug;53(8):1168-75. doi: 10.3109/13880209.2014.967783. Epub 2015 Apr 10. PubMed PMID: 25857699.

6: Jung YR, Kim DH, Kim SR, An HJ, Lee EK, Tanaka T, Kim ND, Yokozawa T, Park JN, Chung HY. Anti-wrinkle effect of magnesium lithospermate B from Salvia miltiorrhiza BUNGE: inhibition of MMPs via NF-kB signaling. PLoS One. 2014 Aug 6;9(8):e102689. doi: 10.1371/journal.pone.0102689. eCollection 2014. PubMed PMID: 25099178; PubMed Central PMCID: PMC4123883.7: Quan W, Wu B, Bai Y, Zhang X, Yin J, Xi M, Guan Y, Shao Q, Chen Y, Wu Q, Wen A. Magnesium lithospermate B improves myocardial function and prevents simulated ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis through Akt-dependent pathway. J Ethnopharmacol. 2014;151(1):714-21. doi: 10.1016/j.jep.2013.11.036. Epub 2013 Dec 1. PubMed PMID: 24296090.8: Jung YR, Lee EK, Kim DH, Park CH, Park MH, Jeong HO, Yokozawa T, Tanaka T, Im DS, Kim ND, Yu BP, Mo SH, Chung HY. Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza. J Nat Prod. 2015 Aug 28;78(8):2110-5. doi: 10.1021/acs.jnatprod.5b00348. Epub 2015 Aug 17. PubMed PMID: 26280594.9: Jiang X, Zhong L, Sun D, Rong L. Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway. Environ Toxicol Pharmacol. 2016 Jan;41:72-7. doi: 10.1016/j.etap.2015.10.009. Epub 2015 Nov 10. PubMed PMID: 26650800.10: Chang CZ, Wu SC, Kwan AL, Lin CL. Magnesium Lithospermate B Implicates 3'-5'-Cyclic Adenosine Monophosphate/Protein Kinase A Pathway and N-Methyl-d-Aspartate Receptors in an Experimental Traumatic Brain Injury. World Neurosurg. 2015 Oct;84(4):954-63. doi: 10.1016/j.wneu.2015.05.075. Epub 2015 Jun 18. PubMed PMID: 26093361.1

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