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6138-47-2
  • Liothyronine HCl

  • names:

    (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid hydrochloride

  • CAS号:

    6138-47-2

    MDL Number:
  • MF(分子式): C15H13ClI3NO4 MW(分子量): 687.4354
  • EINECS: Reaxys Number:
  • Pubchem ID: Brand:BIOFOUNT
Liothyronine HCl
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中文别名 Liothyronine HCl
英文别名 Liothyronine; L-Liothyronine; L-T3; Liotironina; Triiodothyronine; NSC 80203; NSC-80203; NSC80203;
CAS号 6138-47-2
SMILES O=C(O)[C@@H](N)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1.[H]Cl
Inchi InChI=1S/C15H12I3NO4.ClH/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);1H/t12-;/m0./s1
InchiKey HFEMPWKWYHWPQX-YDALLXLXSA-N
分子式 Formula C15H13ClI3NO4
分子量 Molecular Weight 687.4354
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状 Solid powder
储藏条件 Storage conditions Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).
产品说明 Liothyronine HCl(CAS:6138-47-2 ):仅限应用于工业或者科学研究过程中非医疗目的,不应用于人类或动物的临床诊断以及治过程疗,该产品非药用,非食用。
IntroductionLiothyronine is a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Application1
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危险性 Warning
危险性警示
安全声明
安全防护
备注
[1]Huang HB, Kuo PL, Chang JW, Jaakkola JJK, Liao KW, Huang PC. Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS). Sci Total Environ. 2018 Apr 1;619-620:1058-1065. doi: 10.1016/j.scitotenv.2017.11.048. Epub 2017 Nov 29. PubMed PMID: 29734584.
[2]Beukhof CM, Massolt ET, Visser TJ, Korevaar TIM, Medici M, de Herder WW, Roeters van Lennep JE, Mulder MT, de Rijke YB, Reiners C, Verburg FA, Peeters RP. Effects of Thyrotropin on Peripheral Thyroid Hormone Metabolism and Serum Lipids. Thyroid. 2018 Feb;28(2):168-174. doi: 10.1089/thy.2017.0330. Epub 2018 Feb 1. PubMed PMID: 29316865.
[3] Jinguji M, Nakajo M, Nakajo M, Koriyama C, Yoshiura T. Thymic Involution After Radioiodine Therapy for Graves Disease: Relationships With Serum Thyroid Hormones and TRAb. J Endocr Soc. 2017 Jun 5;1(7):852-860. doi: 10.1210/js.2017-00182. eCollection 2017 Jul 1. PubMed PMID: 29264536; PubMed Central PMCID: PMC5686677.
[4] Reinling J, Houde M, Verreault J. Environmental exposure to a major urban wastewater effluent: Effects on the energy metabolism of northern pike. Aquat Toxicol. 2017 Oct;191:131-140. doi: 10.1016/j.aquatox.2017.08.003. Epub 2017 Aug 4. PubMed PMID: 28837883.
[5] Du W, Dong Q, Lu X, Liu X, Wang Y, Li W, Pan Z, Gong Q, Liang C, Gao G. Iodine-131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease. Exp Ther Med. 2017 Mar;13(3):1155-1159. doi: 10.3892/etm.2017.4047. Epub 2017 Jan 16. PubMed PMID: 28450957; PubMed Central PMCID: PMC5403523.
6: Samadi R, Ghanbari M, Shafiei B, Gheibi S, Azizi F, Ghasemi A. High dose of radioactive iodine per se has no effect on glucose metabolism in thyroidectomized rats. Endocrine. 2017 May;56(2):399-407. doi: 10.1007/s12020-017-1274-9. Epub 2017 Mar 10. PubMed PMID: 28283939.7: Yue Z, Yu M, Zhang X, Dong Y, Tian H, Wang W, Ru S. Semicarbazide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus) and its potential mechanisms. Ecotoxicol Environ Saf. 2017 Jun;140:131-140. doi: 10.1016/j.ecoenv.2017.02.043. Epub 2017 Feb 28. PubMed PMID: 28254723.8: Wang R, Tan J, Zhang G, Zheng W, Li C. Risk factors of hepatic dysfunction in patients with Graves' hyperthyroidism and the efficacy of 131iodine treatment. Medicine (Baltimore). 2017 Feb;96(5):e6035. doi: 10.1097/MD.0000000000006035. PubMed PMID: 28151911; PubMed Central PMCID: PMC5293474.9: Padma S, Sundaram PS. Radioiodine as an adjuvant therapy and its role in follow-up of differentiated thyroid cancer. J Cancer Res Ther. 2016 Jul-Sep;12(3):1109-1113. doi: 10.4103/0973-1482.163677. Review. PubMed PMID: 28054519.10: Iglesias P, Bajo MA, Selgas R, Díez JJ. Thyroid dysfunction and kidney disease: An update. Rev Endocr Metab Disord. 2017 Mar;18(1):131-144. doi: 10.1007/s11154-016-9395-7. Review. PubMed PMID: 27864708.1
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