130304-58-4|L 687781|L 687781|-范德生物科技公司

L 687781

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names：
L 687781
CAS号：
130304-58-4
MDL Number：
MF(分子式)： C47H66O17 MW(分子量)： 903.02
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3',5,7-trihydroxy-6'-(hydroxymethyl)-5'-((3,4,5-trihydroxy-6-((((2E,4E)-8-hydroxydeca-2,4-dienoyl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-4'-yl (2E,4E,8E,10E)-7-hydroxy-8,14-dimethylhexadeca-2,4,8,10-tetraenoate
英文别名	L 687781; L-687781; L687781; L-687,781; L 687,781; L687,781;
CAS号	130304-58-4
Inchi	InChI=1S/C47H66O17/c1-5-28(3)17-11-9-12-18-29(4)33(51)20-14-10-16-22-38(54)62-44-43(35(25-48)64-47(45(44)58)39-30(26-60-47)23-32(50)24-34(39)52)63-46-42(57)41(56)40(55)36(61-46)27-59-37(53)21-15-8-7-13-19-31(49)6-2/h7-10,12,14-16,18,21-24,28,31,33,35-36,40-46,48-52,55-58H,5-6,11,13,17,19-20,25-27H2,1-4H3/b8-7+,12-9+,14-10+,21-15+,22-16+,29-18+
InchiKey	YKYGJTLYLZXNDB-WUUUWWERSA-N
分子式 Formula	C47H66O17
分子量 Molecular Weight	903.02
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 687781(CAS:130304-58-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 687781 is a natural product that is a member of the papulacandin family; a 1,3-beta-glucan synthesis inhibitor; used in treatment of Pneumocystis carinii pneumonia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kurtz MB, Abruzzo G, Flattery A, Bartizal K, Marrinan JA, Li W, Milligan J, Nollstadt K, Douglas CM. Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies. Infect Immun. 1996 Aug;64(8):3244-5[1]PubMed PMID: 8757860; PubMed Central PMCID: PMC174214.

[2]Aoki M, Andoh T, Ueki T, Masuyoshi S, Sugawara K, Oki T. BU-4794F, a new beta-1,3-glucan synthase inhibitor. J Antibiot (Tokyo). 1993 Jun;46(6):952-60. PubMed PMID: 8344877.

[3] Bartizal K, Abruzzo G, Trainor C, Krupa D, Nollstadt K, Schmatz D, Schwartz R, Hammond M, Balkovec J, Vanmiddlesworth F. In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin. Antimicrob Agents Chemother. 1992 Aug;36(8):1648-57. PubMed PMID: 1416847; PubMed Central PMCID: PMC192025.

[4] VanMiddlesworth F, Omstead MN, Schmatz D, Bartizal K, Fromtling R, Bills G, Nollstadt K, Honeycutt S, Zweerink M, Garrity G, et al. L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity. J Antibiot (Tokyo). 1991 Jan;44(1):45-51. PubMed PMID: 2001985.

[5] Schmatz DM, Romancheck MA, Pittarelli LA, Schwartz RE, Fromtling RA, Nollstadt KH, Vanmiddlesworth FL, Wilson KE, Turner MJ. Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5950-4. PubMed PMID: 2198575; PubMed Central PMCID: PMC54447.

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