
-
Elubrixin free base
- names:
1-(4-chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea
- CAS号:
688763-64-6
MDL Number: - MF(分子式): C17H17Cl2FN4O4S MW(分子量): 463.3054
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
---|
中文别名 | Elubrixin free base |
英文别名 | SB-656933; SB 656933; SB656933; SB-656933-AAF; SB-656933 AAF; SB-656933AAF; Elubrixin |
CAS号 | 688763-64-6 |
SMILES | FC1=C(Cl)C(NC(NC2=CC=C(Cl)C(S(=O)(N3CCNCC3)=O)=C2O)=O)=CC=C1 |
Inchi | InChI=1S/C17H17Cl2FN4O4S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24/h1-5,21,25H,6-9H2,(H2,22,23,26) |
InchiKey | YQYFEGTYCUQBEI-UHFFFAOYSA-N |
分子式 Formula | C17H17Cl2FN4O4S |
分子量 Molecular Weight | 463.3054 |
闪点 FP | |
熔点 Melting point | |
沸点 Boiling point | |
Polarizability极化度 | |
密度 Density | |
蒸汽压 Vapor Pressure | |
溶解度Solubility | |
性状 | Solid powder |
储藏条件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
产品说明 | Elubrixin free base(CAS:688763-64-6 ):仅限应用于工业或者科学研究过程中非医疗目的,不应用于人类或动物的临床诊断以及治过程疗,该产品非药用,非食用。 |
Introduction | Elubrixin, also known as SB-656933 or SB-656933-AAF, is a interleukin 8 inhibitor and CXCR2 selective antagonist, which is potentially useful for Inflammatory bowel disease therapies. Elubrixin inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. demonstrates dose-dependent effects on neutrophil activation and recruitment within a well-tolerated dose range. SB-656933 may be an effective agent in neutrophil-predominant diseases. |
Application1 | |
Application2 | |
Application3 |
[1]Kaur M, Singh D. Neutrophil chemotaxis caused by chronic obstructive pulmonarydisease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2. JPharmacol Exp Ther. 2013 Oct;347(1):173-80. doi: 10.1124/jpet.112.201855. Epub2013 Aug 2. PubMed PMID: 23912333. |
[2]Moss RB, Mistry SJ, Konstan MW, Pilewski JM, Kerem E, Tal-Singer R, Lazaar AL;CF2110399 Investigators. Safety and early treatment effects of the CXCR2antagonist SB-656933 in patients with cystic fibrosis. J Cyst Fibros. 2013May;12(3):241-8. doi: 10.1016/j.jcf.2012.08.016. Epub 2012 Sep 17. PubMed PMID:22995323. |
[3] Aul R, Patel S, Summerhill S, Kilty I, Plumb J, Singh D. LPS challenge inhealthy subjects: an investigation of neutrophil chemotaxis mechanisms involvingCXCR1 and CXCR2. Int Immunopharmacol. 2012 Jul;13(3):225-31. doi:10.1016/j.intimp.2012.04.008. Epub 2012 May 2. PubMed PMID: 22561413. |
[4] Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Tal-Singer R.SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophilactivation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol.2011 Aug;72(2):282-93. doi: 10.1111/j.1365-2125.2011.03968.x. PubMed PMID:21426372; PubMed Central PMCID: PMC3162658. |
[5] Nicholson GC, Tennant RC, Carpenter DC, Sarau HM, Kon OM, Barnes PJ, Salmon M,Vessey RS, Tal-Singer R, Hansel TT. A novel flow cytometric assay of human wholeblood neutrophil and monocyte CD11b levels: upregulation by chemokines is relatedto receptor expression, comparison with neutrophil shape change, and effects of achemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 2007;20(1):52-9. Epub2006 Jan 6. PubMed PMID: 16406722. |
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