119942-75-5|Delequamine HCl|(8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine monohydrochloride|-范德生物科技公司

Delequamine HCl

NMR下载 COA and HPLC MSDS下载
names：
(8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine monohydrochloride
CAS号：
119942-75-5
MDL Number：
MF(分子式)： C18H27ClN2O3S MW(分子量)： 386.935
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Delequamine HCl
英文别名	RS-15385; RS 15385; RS15385; RS-15385-197; Delequamine; Delequamine HCl.
CAS号	119942-75-5
SMILES	O=S(N1CCC[C@]2([H])CN(CCC3=C4C=CC(OC)=C3)[C@@]4([H])C[C@]12[H])(C)=O.[H]Cl
Inchi	InChI=1S/C18H26N2O3S.ClH/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19;/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3;1H/t14-,17+,18+;/m1./s1
InchiKey	ITJOISLXCMAIOC-CVLULELNSA-N
分子式 Formula	C18H27ClN2O3S
分子量 Molecular Weight	386.935
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Delequamine HCl(CAS:119942-75-5 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Delequamine, also known RS-15385 or RS-15385-197 (HCl salt), is a potent and selective alpha 2-adrenoceptor antagonist. RS-15385-197 had a pKi of 9.45 for alpha 2-adrenoceptors in the rat cortex (pA2 in the guinea-pig ileum of 9.72). RS-15385-197 was highly selective for alpha 2-adrenoceptors over other receptors the compound showed low affinity for 5-HT1A (pKi 6.50) and 5-HT1D (pKi 7.00) receptor subtypes, and even lower affinity (pKi < or = 5) for other 5-HT receptor subtypes, dopamine receptors, muscarinic cholinoceptors, beta-adrenoceptors and dihydropyridine binding sites.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Padma-Nathan H, Christ G, Adaikan G, Becher E, Brock G, Carrier S, Carson C, Corbin J, Francis S, DeBusk R, Eardley I, Hedlund H, Hutter A, Jackson G, Kloner R, Lin CS, McVary K, McCullough A, Nehra A, Porst H, Schulman C, Seftel A, Sharlip I, Stief C, Teloken C. Pharmacotherapy for erectile dysfunction. J Sex Med. 2004 Sep;1(2):128-40. Erratum in: J Sex Med. 2005 Jan;2(1):158. Lin, Shin [corrected to Lin, Ching-Shwun]. PubMed PMID: 16422967.

[2]Kim NN, Min K, Huang YH, Goldstein I, Traish AM. Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina. Life Sci. 2002 Nov 1;71(24):2909-20. PubMed PMID: 12377271.

[3] Allard J, Giuliano F. Central nervous system agents in the treatment of erectile dysfunction: how do they work? Curr Urol Rep. 2001 Dec;2(6):488-94. Review. PubMed PMID: 12084236.

[4] Hume SP, Hirani E, Opacka-Juffry J, Osman S, Myers R, Gunn RN, McCarron JA, Clark RD, Melichar J, Nutt DJ, Pike VW. Evaluation of [O-methyl-11C]RS-15385-197 as a positron emission tomography radioligand for central alpha2-adrenoceptors. Eur J Nucl Med. 2000 May;27(5):475-84. PubMed PMID: 10853800.

[5] Bancroft J. Effects of alpha-2 blockade on sexual response: experimental studies with delequamine (RS15385). Int J Impot Res. 2000 Mar;12 Suppl [5]S64-69. Review. PubMed PMID: 10845766.

6: Saenz de Tejada I, Kim NN, Goldstein I, Traish AM. Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. Int J Impot Res. 2000 Mar;12 Suppl 1:S20-25. Review. PubMed PMID: 10845761.7: Bancroft J. Effects of alpha-2 blockade on sexual response: experimental studies with Delequamine (RS15385). Int J Impot Res. 2000 Mar;12(S1):S64-S69. PubMed PMID: 10849567.8: Spedding M, Newman-Tancredi A, Millan MJ, Dacquet C, Michel AN, Jacoby E, Vickery B, Tallentire D. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. 1998 Jun;37(6):769-80. PubMed PMID: 9707291.9: Gonzalez MI, Patmore L, Wilson CA. Effect of delequamine (RS15385) on female sexual behaviour in the rat. Eur J Pharmacol. 1996 Sep 19;312(1):1-6. PubMed PMID: 8891572.10: Tallentire D, McRae G, Spedding M, Clark R, Vickery B. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72. PubMed PMID: 8733577; PubMed Central PMCID: PMC1909492.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开