1427001-89-5|AMY-101|AMY-101|-范德生物科技公司

AMY-101

NMR下载 COA and HPLC MSDS下载
names：
AMY-101
CAS号：
1427001-89-5
MDL Number：
MF(分子式)： C83H117N23O18S2 MW(分子量)： 1789.11
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10-((1H-imidazol-5-yl)methyl)-19-((1H-indol-3-yl)methyl)-34-((2S,3S)-2-((R)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-(((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)(methyl)carbamoyl)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-31-isopropyl-13,17-dimethyl-28-((1-methyl-1H-indol-3-yl)methyl)-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid
英文别名	AMY-101; AMY 101; AMY101;Compstatin 40; CP40; CP 40; CP-40;
CAS号	1427001-89-5
SMILES	O=C(O)C[C@H](NC([C@H](CCC(N)=O)NC([C@H](CC1=CN(C)C2=C1C=CC=C2)NC([C@H](C(C)C)N3)=O)=O)=O)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N(C)CC(N[C@@H](C)C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N([C@@H]([C@@H](C)CC)C(N)=O)C)=O)CSSC[C@H](NC([C@@H](NC([C@H](N)CC7=CC=C(O)C=C7)=O)[C@@H](C)CC)=O)C3=O)=O)=O)=O)=O)=O)=O
Inchi	InChI=1S/C83H117N23O18S2/c1-11-43(5)68(103-72(114)53(84)30-46-23-25-50(107)26-24-46)80(122)100-61-39-125-126-40-62(82(124)106(10)69(70(86)112)44(6)12-2)101-73(115)55(21-17-29-90-83(87)88)94-76(118)58(33-49-36-89-41-92-49)96-71(113)45(7)93-65(109)38-105(9)81(123)60(31-47-35-91-54-20-15-13-18-51(47)54)99-77(119)59(34-66(110)111)97-74(116)56(27-28-64(85)108)95-75(117)57(98-79(121)67(42(3)4)102-78(61)120)32-48-37-104(8)63-22-16-14-19-52(48)63/h13-16,18-20,22-26,35-37,41-45,53,55-62,67-69,91,107H,11-12,17,21,27-34,38-40,84H2,1-10H3,(H2,85,108)(H2,86,112)(H,89,92)(H,93,109)(H,94,118)(H,95,117)(H,96,113)(H,97,116)(H,98,121)(H,99,119)(H,100,122)(H,101,115)(H,102,120)(H,103,114)(H,110,111)(H4,87,88,90)/t43-,44-,45-,53+,55-,56-,57-,58-,59-,60-,61-,62-,67-,68-,69-/m0/s1
InchiKey	MUSGYEMSJUFFHT-UWABRSFTSA-N
分子式 Formula	C83H117N23O18S2
分子量 Molecular Weight	1789.11
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AMY-101(CAS:1427001-89-5 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AMY-101 is a peptidic inhibitor of the central complement component C3.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kajikawa T, Briones RA, Resuello RRG, Tuplano JV, Reis ES, Hajishengallis E, Garcia CAG, Yancopoulou D, Lambris JD, Hajishengallis G. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;

6:207-215. doi: 10.1016/j.omtm.2017.08.001. eCollection 2017 Sep 15. PubMed PMID: 28879212; PubMed Central PMCID: PMC5577415.

[3]Mastellos DC, Reis ES, Yancopoulou D, Hajishengallis G, Ricklin D, Lambris JD. From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage. Immunobiology. 2016 Oct;221(10):1046-57. doi: 10.1016/j.imbio.2016.06.013. Epub 2016 Jun 16. Review. PubMed PMID: 27353192; PubMed Central PMCID: PMC4987232.

[4]Mastellos DC, Ricklin D, Yancopoulou D, Risitano A, Lambris JD. Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape. Expert Rev Hematol. 2014 Oct;7(5):583-98. doi: 10.1586/17474086.2014.953926. Epub 2014 Sep 2. Review. PubMed PMID: 25213458; PubMed Central PMCID: PMC4383744.

[5] Mastellos DC, Reis ES, Ricklin D, Smith RJ, Lambris JD. Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery. Trends Immunol. 2017 Jun;38(6):383-394. doi: 10.1016/j.it.2017.03.003. Epub 2017 Apr 14. PubMed PMID: 28416449; PubMed Central PMCID: PMC5447467.

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