151232-75-6|Allotrap|Allotrap|-范德生物科技公司

Allotrap

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names：
Allotrap
CAS号：
151232-75-6
MDL Number：
MF(分子式)： C53H90N20O16 MW(分子量)： 1263.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK11099-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	(2S,8S,11S,14S,17S,20S,23S,26S)-14-(2-amino-2-oxoethyl)-26-((S)-2-amino-5-guanidinopentanamido)-8,17-bis(3-guanidinopropyl)-2-(4-hydroxybenzyl)-23-(hydroxymethyl)-11,20-diisobutyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazanonacosanedioic acid
英文别名	Allotrap; Peptide Bc-1nl;
CAS号	151232-75-6
SMILES	OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O)=O)=O)=O)=O)=O
Inchi	InChI=1S/C53H90N20O16/c1-26(2)20-34(46(84)68-31(9-6-18-63-52(58)59)43(81)65-24-40(77)66-37(50(88)89)22-28-11-13-29(75)14-12-28)70-48(86)36(23-39(55)76)72-44(82)32(10-7-19-64-53(60)61)69-47(85)35(21-27(3)4)71-49(87)38(25-74)73-45(83)33(15-16-41(78)79)67-42(80)30(54)8-5-17-62-51(56)57/h11-14,26-27,30-38,74-75H,5-10,15-25,54H2,1-4H3,(H2,55,76)(H,65,81)(H,66,77)(H,67,80)(H,68,84)(H,69,85)(H,70,86)(H,71,87)(H,72,82)(H,73,83)(H,78,79)(H,88,89)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64)/t30-,31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
InchiKey	KXASYRUYKYOKGG-IWLMWFOOSA-N
分子式 Formula	C53H90N20O16
分子量 Molecular Weight	1263.42
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Allotrap(CAS:151232-75-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Allotrap is a small synthetic peptide derived from the alpha1 helix of the heavy chain of HLA class I proteins; inhibits human T cell responses in vitro; prolongs allograft survival in rats and mice.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tice DG, Bruch D, Buelow R, Squiers EC. Survival of rat small bowel allografts treated with allotrap 07R. J Surg Res. 1997 Sep;72(1):78-83. PubMed PMID: 9344717.

[2]Iyer S, Kontoyiannis D, Chevrier D, Woo J, Mori N, Cornejo M, Kollias G, Buelow R. Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide. J Biol Chem. 2000 Jun 2;275(22):17051-7. PubMed PMID: 10748117.

[3] Buelow R, Veyron P, Clayberger C, Pouletty P, Touraine JL. Prolongation of skin allograft survival in mice following administration of ALLOTRAP. Transplantation. 1995 Feb 27;59(4):455-60. PubMed PMID: 7878745.

[4] Oberyszyn TM, Robertson FM, Tober KL, Ross MS, Parrett ML, Wilgus TA, Iyer S, Woo J, Buelow R. Inhibition of cutaneous UV light-induced tumor necrosis factor-alpha protein production by Allotrap 1258, a novel immunomodulatory peptide. Photochem Photobiol. 2001 Feb;73(2):184-90. PubMed PMID: 11272733.

[5] Gao L, Woo J, Buelow R. Both L- and D-isomers of allotrap 2702 prolong cardiac allograft survival in mice. J Heart Lung Transplant. 1996 Jan;15(1 Pt 1):78-87. PubMed PMID: 8820086.

6: Li W, Iyer S, Lu L, Buelow R, Fung JJ, Rao AS, Woo J, Qian S. Attenuation of aortic graft arteriosclerosis by systemic administration of Allotrap peptide RDP58. Transpl Int. 2003 Dec;16(12):849-56. Epub 2003 Aug 27. PubMed PMID: 12942166.7: Squiers EC, Hodell M, Beulow R. Allotrap prolongs survival of porcine islet xenografts in diabetic mice. Transplant Proc. 1997 Jun;29(4):2168-9. PubMed PMID: 9193574.8: Masroor S, Itescu S, Artrip JH, Minanov OP, Buelow R, Michler RE. Induction of tolerance in rodent cardiac allotransplantation using an MHC class I-derived peptide and cyclosporin A. Ann Thorac Surg. 1998 Jan;65(1):144-8. PubMed PMID: 9456108.9: Yu X, Song B, Huang C, Xiao Y, Fang M, Feng J, Wang P, Zhang G. Prolonged survival time of allografts by the oral administration of RDP58 linked to the cholera toxin B subunit. Transpl Immunol. 2012 Oct;27(2-3):122-7. doi: 10.1016/j.trim.2012.06.004. Epub 2012 Jun 15. PubMed PMID: 22709942.10: Tice DG, Bruch D, Squiers EC. Graft survival and MLC response in LEW-ACI small bowel transplants treated with a novel MHC peptide, BC-1nl. Transplant Proc. 1998 Sep;30(6):2590-1. PubMed PMID: 9745504.1

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