210344-95-9|Z-DEVD-fmk|Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor|-范德生物科技公司

Z-DEVD-fmk

NMR下载 COA and HPLC MSDS下载
names：
Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor
CAS号：
210344-95-9
MDL Number：
MF(分子式)： C30H41FN4O12 MW(分子量)： 668.67
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Z-D(OMe)E(OMe)VD(OMe)-FMK，细胞渗透性caspase-3抑制剂;methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
英文别名	Z-D(OMe)E(OMe)VD(OMe)-FMK, Cell permeable caspase-3 inhibitor;Z-DEVD-fmk; Z DEVD fmk; ZDEVDfmk;
CAS号	210344-95-9
SMILES	O=C(OC)CC[C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(OC)=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O
Inchi	InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InchiKey	GBJVAVGBSGRRKN-JYEBCORGSA-N
分子式 Formula	C30H41FN4O12
分子量 Molecular Weight	668.67
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Z-DEVD-fmk(CAS:210344-95-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Z-DEVD-fmk is a cell-permeable, irreversible inhibitor of caspase-3. Caspase-3 is a cysteinyl aspartate-specific protease which plays a central role in apoptosis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Yemisci M, Caban S, Fernandez-Megia E, Capan Y, Couvreur P, Dalkara T. Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides. Methods Mol Biol. 2018;1727:443-454. doi: 10.1007/978-1-4939-7571-6_36. PubMed PMID: 29222804.

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[4] Zhou P, Dong XX, Tang P. [Sanggenon C induces apoptosis of prostate cancer PC3 cells by activating caspase 3 and caspase 9 pathways]. Nan Fang Yi Ke Da Xue Xue Bao. 2017 Sep 20;37(9):1206-1210. Chinese. PubMed PMID: 28951363.

[5] Yang Y, Du J, Liu F, Wang X, Li X, Li Y. Role of caspase-3/E-cadherin in helicobacter pylori-induced apoptosis of gastric epithelial cells. Oncotarget. 2017 Jul 22;8(35):59204-59216. doi: 10.18632/oncotarget.19471. eCollection 2017 Aug 29. PubMed PMID: 28938629; PubMed Central PMCID: PMC5601725.

6: Pyrshev KA, Yesylevskyy SO, Mély Y, Demchenko AP, Klymchenko AS. Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. Biochim Biophys Acta. 2017 Oct;1859(10):2123-2132. doi: 10.1016/j.bbamem.2017.08.002. Epub 2017 Aug 5. PubMed PMID: 28784460.7: Shang HS, Shih YL, Lu TJ, Lee CH, Hsueh SC, Chou YC, Lu HF, Liao NC, Chung JG. Benzyl isothiocyanate (BITC) induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells via activation of caspase-8/Bid and the reactive oxygen species-dependent mitochondrial pathway. Environ Toxicol. 2016 Dec;31(12):1751-1760. doi: 10.1002/tox.22177. Epub 2015 Sep 7. PubMed PMID: 28675694.8: Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A, Li W. Arctigenin, a natural lignan compound, induces G(0)/G(1) cell cycle arrest and apoptosis in human glioma cells. Oncol Lett. 2017 Feb;13(2):1007-1013. doi: 10.3892/ol.2016.5474. Epub 2016 Dec 8. PubMed PMID: 28356992; PubMed Central PMCID: PMC5351207.9: Chen CH, Chen MF, Huang SJ, Huang CY, Wang HK, Hsieh WC, Huang CH, Liu LF, Shiu LY. Saikosaponin a Induces Apoptosis through Mitochondria-Dependent Pathway in Hepatic Stellate Cells. Am J Chin Med. 2017;45(2):351-368. doi: 10.1142/S0192415X17500227. Epub 2017 Feb 23. PubMed PMID: 28231747.10: Zhu H, Tan L, Li Y, Li J, Qiu M, Li L, Zhang M, Liang M, Li A. Increased Apoptosis in the Paraventricular Nucleus Mediated by AT1R/Ras/ERK1/2 Signaling Results in Sympathetic Hyperactivity and Renovascular Hypertension in Rats after Kidney Injury. Front Physiol. 2017 Feb 2;8:41. doi: 10.3389/fphys.2017.00041. eCollection 2017. PubMed PMID: 28210225; PubMed Central PMCID: PMC5288364.1

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