124916-54-7|Way 120491|2-(3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)chroman-4-yl)isoindolin-1-one|-范德生物科技公司

Way 120491

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names：
2-(3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)chroman-4-yl)isoindolin-1-one
CAS号：
124916-54-7
MDL Number：
MF(分子式)： C20H18F3NO4 MW(分子量)： 393.3622
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2-(3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)chroman-4-yl)isoindolin-1-one
英文别名	Way-120,491; Way120491; Way-120491; Way 120491; Celikalim
CAS号	124916-54-7
SMILES	O=C1N(C2C(O)C(C)(C)OC3=CC=C(OC(F)(F)F)C=C23)CC4=C1C=CC=C4
Inchi	InChI=1S/C20H18F3NO4/c1-19(2)17(25)16(24-10-11-5-3-4-6-13(11)18(24)26)14-9-12(27-20(21,22)23)7-8-15(14)28-19/h3-9,16-17,25H,10H2,1-2H3
InchiKey	ZORATYFUTXFLJS-UHFFFAOYSA-N
分子式 Formula	C20H18F3NO4
分子量 Molecular Weight	393.3622
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Way 120491(CAS:124916-54-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Way 120491 activates ATP-sensitive potassium channels.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]de Lorenzi FG. Celikalim (WAY-120491) increases K+ outward flux in dog and human airway smooth muscle. Pulm Pharmacol. 1994 Apr;7(2):129-35. PubMed PMID: 8081073.

[2]Wojdan A, Freeden C, Woods M, Oshiro G, Spinelli W, Colatsky TJ, Sheldon JH, Norton NW, Warga D, Antane MM, Antane SA, Butera JA, Argentieri TM. Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat. J Pharmacol Exp Ther. 1999 Jun;289(3):1410-8. PubMed PMID: 10336534.

[3] Furspan PB. WAY 120,491 activates ATP-sensitive potassium channels in rat tail artery. Eur J Pharmacol. 1992 Nov 17;223(2-3):201-3. PubMed PMID: 1478268.

[4] Evans JM, Smith RJ, Stemp G. Separation of the enantiomers of some potassium channel activators using an alpha 1-acid glycoprotein column. J Chromatogr. 1992 Oct 9;623(1):163-7. PubMed PMID: 1452627.

[5] Kitzen JM, McCallum JD, Harvey C, Morin ME, Oshiro GT, Colatsky TJ. Potassium channel activators cromakalim and celikalim (WAY-120,491) fail to decrease myocardial infarct size in the anesthetized canine. Pharmacology. 1992;45(2):71-82. PubMed PMID: 1523216.

6: Hohman TC, Cotter MA, Cameron NE. ATP-sensitive K(+) channel effects on nerve function, Na(+), K(+) ATPase, and glutathione in diabetic rats. Eur J Pharmacol. 2000 Jun 2;397(2-3):335-41. PubMed PMID: 10844132.7: Patelunas-Hoffman DM, Carmint WJ, Colatsky TJ, Fenichel RL. Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis. Thromb Res. 1994 Jun 1;74(5):441-52. PubMed PMID: 8085245.8: Lodge NJ, Colatsky TJ, Cullinan CA, Follmer CH. Electromechanical effects of the putative potassium channel activator celikalim (WAY-120,491) on feline atrial and ventricular muscle. J Pharmacol Exp Ther. 1992 Jun;261(3):1153-9. PubMed PMID: 1602381.9: Lodge NJ, Cohen RB, Havens CN, Colatsky TJ. The effects of the putative potassium channel activator WAY-120,491 on 86Rb efflux from the rabbit aorta. J Pharmacol Exp Ther. 1991 Feb;256(2):639-44. PubMed PMID: 1899702.

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