73621-92-8|Viprostol|Prosta-5,13-dien-1-oic acid, 16-ethenyl-11,16-dihydroxy-9-oxo-, methyl ester, (5Z,11alpha,13E)-|-范德生物科技公司

Viprostol

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names：
Prosta-5,13-dien-1-oic acid, 16-ethenyl-11,16-dihydroxy-9-oxo-, methyl ester, (5Z,11alpha,13E)-
CAS号：
73621-92-8
MDL Number：
MF(分子式)： C23H36O5 MW(分子量)： 392.536
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Prosta-5,13-dien-1-oic acid, 16-ethenyl-11,16-dihydroxy-9-oxo-, methyl ester, (5Z,11alpha,13E)-
英文别名	Viprostol; CL 115,347
CAS号	73621-92-8
SMILES	CCCCC(O)(C=C)C/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(OC)=O
Inchi	InChI=1S/C23H36O5/c1-4-6-15-23(27,5-2)16-11-13-19-18(20(24)17-21(19)25)12-9-7-8-10-14-22(26)28-3/h5,7,9,11,13,18-19,21,25,27H,2,4,6,8,10,12,14-17H2,1,3H3/b9-7-,13-11+/t18-,19-,21-,23?/m1/s1
InchiKey	TWCQWABAGCMHLL-ROVQGQOSSA-N
分子式 Formula	C23H36O5
分子量 Molecular Weight	392.536
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Viprostol(CAS:73621-92-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Viprostol is a prostaglandin antihypertensive.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chan PS, Cervoni P, Scully PA, Ronsberg MA, Accomando RC. Mechanism of action of a new prostaglandin antihypertensive, viprostol [CL 115 347; (dl)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 methyl ester]: (I). Vasodilation. J Hypertens. 1986 Dec;4(6):741-7. PubMed PMID: 3029218.

[2]Chan PS, Cervoni P, Accomando RC, Quirk GJ, Ronsberg MA. Mechanism of action of a new prostaglandin antihypertensive, viprostol [CL 115 347; (dl)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 methyl ester]: (II). Effects on the adrenergic nervous system. J Hypertens. 1986 Dec;4(6):749-57. PubMed PMID: 2880911.

[3] Olsen EA, DeLong E. Transdermal viprostol in the treatment of male pattern baldness. J Am Acad Dermatol. 1990 Sep;23(3 Pt 1):470-2. PubMed PMID: 2212146.

[4] Nicolau G, Cosulich DB, Tonelli A, Chen SM, Pruzinsky MS, Blum D. Metabolism of viprostol--a synthetic vasodilator PGE2 analog. Prostaglandins. 1986 Apr;31(4):811-27. PubMed PMID: 3088678.

[5] Cervoni P, Chan PS. Synthetic stable orally and transdermally long-acting prostaglandin E2 (PGE2) congener (viprostol; CL 115,347) and prostacyclin congener (CL 115,999) as antihypertensive agents. Adv Prostaglandin Thromboxane Leukot Res. 1989;19:331-4. PubMed PMID: 2526492.

6: Olivari MT, Levine TB, Cohn JN. Evidence for a direct renal stimulating effect of prostaglandin E2 on renin release in patients with congestive heart failure. Circulation. 1986 Dec;74(6):1203-7. PubMed PMID: 3536150.7: Belch JJ, O'Dowd A, Forbes CD, Sturrock RD. Platelet sensitivity to a prostacyclin analogue in systemic sclerosis. Br J Rheumatol. 1985 Nov;24(4):346-50. PubMed PMID: 2415199.8: Lai FM, Tanikella TK, Cervoni P. The vasorelaxant effect of (+/-)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 (CL 115, 129) and its methyl ester (CL 115, 347) on the isolated ductus arteriosus preparation. Life Sci. 1984 May 7;34(19):1861-6. PubMed PMID: 6588286.9: Lai FM, Cobuzzi A, Tanikella T, Cervoni P. Relaxant actions of viprostol and prostaglandin E2 on tracheal muscle and their effects on calcium influx. Prostaglandins. 1988 Jul;36(1):115-23. PubMed PMID: 3175022.10: Chatziantoniou C, Arendshorst WJ. Prostaglandin interactions with angiotensin, norepinephrine, and thromboxane in rat renal vasculature. Am J Physiol. 1992 Jan;262(1 Pt 2):F68-76. PubMed PMID: 1733298.1

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