104420-17-9|Toxin IIc|2,4,6-Octatrienoic acid, 8-((2-hydroxy-3-methyl-1-oxopentyl)oxy)-8-(2-methyloxiranyl)-,(2S-(2R*(2E,4E,6E,8S*(2S*,3R*))))-|-范德生物科技公司

Toxin IIc

NMR下载 COA and HPLC MSDS下载
names：
2,4,6-Octatrienoic acid, 8-((2-hydroxy-3-methyl-1-oxopentyl)oxy)-8-(2-methyloxiranyl)-,(2S-(2R*(2E,4E,6E,8S*(2S*,3R*))))-
CAS号：
104420-17-9
MDL Number：
MF(分子式)： C17H24O6 MW(分子量)： 324.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2,4,6-Octatrienoic acid, 8-((2-hydroxy-3-methyl-1-oxopentyl)oxy)-8-(2-methyloxiranyl)-,(2S-(2R(2E,4E,6E,8S(2S,3R))))-
英文别名	Toxin IIc;
CAS号	104420-17-9
SMILES	O=C(O)/C=C/C=C/C=C/[C@@H](OC(C(O)[C@@H](C)CC)=O)[C@@]1(C)OC1
Inchi	InChI=1S/C17H24O6/c1-4-12(2)15(20)16(21)23-13(17(3)11-22-17)9-7-5-6-8-10-14(18)19/h5-10,12-13,15,20H,4,11H2,1-3H3,(H,18,19)/b6-5+,9-7+,10-8+/t12-,13+,15?,17-/m0/s1
InchiKey	PXZGUAVTZUPRMI-MWOWDIBMSA-N
分子式 Formula	C17H24O6
分子量 Molecular Weight	324.37
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Toxin IIc(CAS:104420-17-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Toxin IIc is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zalem D, Ribeiro JP, Varrot A, Lebens M, Imberty A, Teneberg S. Biochemical and structural characterization of the novel sialic acid-binding site of Escherichia coli heat-labile enterotoxin LT-IIb. Biochem J. 2016 Nov 1;473(21):3923-3936. Epub 2016 Aug 25. PubMed PMID: 27562297.

[2]Jobling MG. The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli. Pathog Dis. 2016 Apr;74(3). pii: ftw001. doi: 10.1093/femspd/ftw001. Epub 2016 Jan 10. PubMed PMID: 26755534; PubMed Central PMCID: PMC4957749.

[3] Hu JC, Greene CJ, King-Lyons ND, Connell TD. The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits. PLoS One. 2015 Nov 13;10(11):e0142942. doi: 10.1371/journal.pone.0142942. eCollection 2015. PubMed PMID: 26565800; PubMed Central PMCID: PMC4643920.

[4] Vance DJ, Greene CJ, Rong Y, Mandell LM, Connell TD, Mantis NJ. Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens. Clin Vaccine Immunol. 2015 Dec;22(12):1285-93. doi: 10.1128/CVI.00402-15. Epub 2015 Oct 21. PubMed PMID: 26491037; PubMed Central PMCID: PMC4658585.

[5] Shahar E, Gorodetsky R, Aizenshtein E, Lalush L, Pitcovski J. Modulating the innate immune activity in murine tumor microenvironment by a combination of inducer molecules attached to microparticles. Cancer Immunol Immunother. 2015 Sep;64(9):1137-49. doi: 10.1007/s00262-015-1719-z. Epub 2015 Jun 2. PubMed PMID: 26031575.

6: Hu JC, Mathias-Santos C, Greene CJ, King-Lyons ND, Rodrigues JF, Hajishengallis G, Ferreira LC, Connell TD. Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen. PLoS One. 2014 Dec 23;9(12):e113978. doi: 10.1371/journal.pone.0113978. eCollection 2014. PubMed PMID: 25536061; PubMed Central PMCID: PMC4275187.7: Bernardoni JL, Sousa LF, Wermelinger LS, Lopes AS, Prezoto BC, Serrano SM, Zingali RB, Moura-da-Silva AM. Functional variability of snake venom metalloproteinases: adaptive advantages in targeting different prey and implications for human envenomation. PLoS One. 2014 Oct 14;9(10):e109651. doi: 10.1371/journal.pone.0109651. eCollection 2014. PubMed PMID: 25313513; PubMed Central PMCID: PMC4196926.8: Camargo AC, Lafisca A, Cossi MV, Lanna FG, Dias MR, de Arruda Pinto PS, Nero LA. Low occurrence of Listeria monocytogenes on bovine hides and carcasses in Minas Gerais State, Brazil: molecular characterization and antimicrobial resistance. J Food Prot. 2014 Jul;77(7):1148-52. doi: 10.4315/0362-028X.JFP-13-434. PubMed PMID: 24988021.9: Berenson CS, Nawar HF, Kruzel RL, Mandell LM, Connell TD. Ganglioside-binding specificities of E. coli enterotoxin LT-IIc: Importance of long-chain fatty acyl ceramide. Glycobiology. 2013 Jan;23(1):23-31. doi: 10.1093/glycob/cws123. Epub 2012 Aug 22. PubMed PMID: 22917572; PubMed Central PMCID: PMC3505011.10: Wu MC, Chen YC, Lin TL, Hsieh PF, Wang JT. Cellobiose-specific phosphotransferase system of Klebsiella pneumoniae and its importance in biofilm formation and virulence. Infect Immun. 2012 Jul;80(7):2464-72. doi: 10.1128/IAI.06247-11. Epub 2012 May 7. PubMed PMID: 22566508; PubMed Central PMCID: PMC3416469.1

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