106413-54-1|TEI-9063|5-[(5R,6R)-5-hydroxy-6-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pentanoic acid|-范德生物科技公司

TEI-9063

NMR下载 COA and HPLC MSDS下载
names：
5-[(5R,6R)-5-hydroxy-6-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pentanoic acid
CAS号：
106413-54-1
MDL Number：
MF(分子式)： C23H38O4 MW(分子量)： 378.55
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	5-[(5R,6R)-5-hydroxy-6-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pentanoic acid
英文别名	TEI-9063; TEI 9063; TEI9063.
CAS号	106413-54-1
SMILES	O=C(O)CCCCC1=CC2C[C@@H](O)[C@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)C2C1
Inchi	InChI=1S/C23H38O4/c1-3-4-7-16(2)12-19(24)10-11-20-21-14-17(8-5-6-9-23(26)27)13-18(21)15-22(20)25/h10-11,13,16,18-22,24-25H,3-9,12,14-15H2,1-2H3,(H,26,27)/b11-10+/t16-,18?,19+,20+,21?,22+/m0/s1
InchiKey	BPNIWRLPDMCZPC-ASUUCAAFSA-N
分子式 Formula	C23H38O4
分子量 Molecular Weight	378.55
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TEI-9063(CAS:106413-54-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TEI-9063 is a stable and highly specific prostacyclin analogue for the prostacyclin receptor in mastocytoma P-815 cells.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chan KM, Jones RL. Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807. PubMed PMID: 15167273.

[2]Jones RL, Chan K. Distinction between relaxations induced via prostanoid EP(4) and IP(1) receptors in pig and rabbit blood vessels. Br J Pharmacol. 2001 Sep;134(2):313-24. PubMed PMID: 11564649; PubMed Central PMCID: PMC1572952.

[3] Tam FS, Chan K, Borreau JP, Jones RL. The mechanisms of enhancement and inhibition of field stimulation responses of guinea-pig vas deferens by prostacyclin analogues. Br J Pharmacol. 1997 Aug;121(7):1413-21. PubMed PMID: 9257922; PubMed Central PMCID: PMC1564834.

[4] Jones RL, Qian YM, Wise H, Wong HN, Lam WL, Chan HW, Yim AP, Ho JK. Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. J Cardiovasc Pharmacol. 1997 Apr;29(4):525-35. PubMed PMID: 9156364.

[5] Qian YM, Jones RL, Chan KM, Stock AI, Ho JK. Potent contractile actions of prostanoid EP3-receptor agonists on human isolated pulmonary artery. Br J Pharmacol. 1994 Oct;113(2):369-74. PubMed PMID: 7834185; PubMed Central PMCID: PMC1510105.

6: Nakaki T, Ohta M, Kato R. Inhibition by prostacyclin and carbacyclins of endothelin-induced DNA synthesis in cultured vascular smooth muscle cells. Prostaglandins Leukot Essent Fatty Acids. 1991 Dec;44(4):237-9. PubMed PMID: 1815238.7: Negishi M, Hashimoto H, Yatsunami K, Kurozumi S, Ichikawa A. TEI-9063, a stable and highly specific prostacyclin analogue for the prostacyclin receptor in mastocytoma P-815 cells. Prostaglandins. 1991 Sep;42(3):225-37. Erratum in: Prostaglandins 1992 Feb;43(2):199. PubMed PMID: 1723528.8: Nakaki T, Ohta M, Kato R. Inhibition of endothelin-1-induced DNA synthesis by prostacyclin and its stable analogues in vascular smooth muscle cells. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S177-8. PubMed PMID: 1725324.9: Tamaki T, Okouchi Y, Kozaki M, Kawamura A, Uchino J, Pegg DE. Hypothermic preservation of the rat liver assessed by orthotopic transplantation. III. Improved functional recovery with isotonic citrate solution and a stable prostacyclin analogue. Transplantation. 1988 Oct;46(4):626-8. PubMed PMID: 3051575.

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