128229-52-7|Tamolarizine free base|2-(4-benzhydrylpiperazin-1-yl)-1-(3,4-dimethoxyphenyl)ethan-1-ol|-范德生物科技公司

Tamolarizine free base

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names：
2-(4-benzhydrylpiperazin-1-yl)-1-(3,4-dimethoxyphenyl)ethan-1-ol
CAS号：
128229-52-7
MDL Number：
MF(分子式)： C27H32N2O3 MW(分子量)： 432.564
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	2-(4-benzhydrylpiperazin-1-yl)-1-(3,4-dimethoxyphenyl)ethan-1-ol
英文别名	NC-1100; NC 1100; NC1100; Tamolarizine; Tamolarizine HCl; Tamolarizine dihyrchloride.
CAS号	128229-52-7
SMILES	OC(C1=CC=C(OC)C(OC)=C1)CN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2
Inchi	InChI=1S/C27H32N2O3/c1-31-25-14-13-23(19-26(25)32-2)24(30)20-28-15-17-29(18-16-28)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-14,19,24,27,30H,15-18,20H2,1-2H3
InchiKey	PIKMDZDCXCAPEF-UHFFFAOYSA-N
分子式 Formula	C27H32N2O3
分子量 Molecular Weight	432.564
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tamolarizine free base(CAS:128229-52-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tamolarizine, also known as NC-1100, a novel calcium antagonist. NC-1100 may show a behavior-facilitating effect, although its effect is mild and different from that of typical central stimulants such as methamphetamine. NC-1100 may be a drug inducing the increase of GABA in the cerebellum and medulla oblongata following continuous administration, especially in animals having hypertension associated cerebrovascular disorders such as SHR-SP.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Miyake N, Fujita R, Ishikawa M, Takayanagi M, Takayanagi Y, Sasaki K. Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000 Mar;82(3):265-8. PubMed PMID: 10887958.

[2]Tamura R, Nakada Y, Nishijo H, Miyake N, Ono T. Ameliorative effects of tamolarizine on place learning impairment induced by transient forebrain ischemia in rats. Brain Res. 2000 Jan 17;853(1):81-92. PubMed PMID: 10627311.

[3] Nomura Y, Yamakawa T, Nishioka K, Omura T, Miyake N, Masaki M, Nohira H. Synthesis and structure-activity relationships of 2-(4-benzhydryl-1-piperazinyl)-1-phenylethanols as new calcium blockers. Chem Pharm Bull (Tokyo). 1995 Feb;43(2):241-6. PubMed PMID: 7537178.

[4] Nishijo H, Tabuchi E, Ono T, Fukuda M, Kuze S, Endo S. Physiological results of monkey brain ischemia, and protection by a calcium blocker. Brain Res Bull. 1995;37(1):89-101. PubMed PMID: 7606483.

[5] Matsumura T, Furuichi H, Izumi J, Kamatsuka Y, Takei M, Nakata N, Ito S, Suda H, Kizaki K, Kurimoto T. [Effects of NC-1100, a calcium channel blocker, on experimental cerebral ischemia/anoxia in rodents]. Nihon Yakurigaku Zasshi. 1993 Mar;101(3):177-86. Japanese. PubMed PMID: 8486322.

6: Miyake N, Wakamori M, Akaike N. A new type of Ca2+ channel blocker, NC-1100, inhibits the low- and high-threshold Ca2+ currents in the rat CNS neurons. Brain Res. 1992 Dec 11;598(1-2):215-20. PubMed PMID: 1486482.7: Sadoshima S, Ibayashi S, Nakane H, Okada Y, Ooboshi H, Fujishima M. Attenuation of ischemic and postischemic damage to brain metabolism and circulation by a novel Ca2+ channel antagonist, NC-1100, in spontaneously hypertensive rats. Eur J Pharmacol. 1992 Dec 2;224(2-3):109-15. PubMed PMID: 1468503.8: Nishijo H, Kuze S, Ono T, Tabuchi E, Endo S, Kogure K. Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus. Brain Res Bull. 1992 Sep-Oct;29(3-4):519-24. PubMed PMID: 1393625.9: Tanabe K, Kinoshita Y, Tokuyoshi K, Houri D, Kimishima K. [Effects of 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol dihydrochloride (NC-1100) on the central nervous system]. Nihon Yakurigaku Zasshi. 1991 Nov;98(5):357-68. Japanese. PubMed PMID: 1813367.10: Miyake N, Takayanagi I. Stereoselectivity of NC-1100, a Ca-entry blocker. Gen Pharmacol. 1990;21(2):261-3. PubMed PMID: 2332145.1

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