1054451-07-8|SMM-189|[4-(3，5-dichlorophenyl)-3，5-dihydroxy-phenyl]-phenyl-methanone|-范德生物科技公司

SMM-189

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names：
[4-(3，5-dichlorophenyl)-3，5-dihydroxy-phenyl]-phenyl-methanone
CAS号：
1054451-07-8
MDL Number：
MF(分子式)： C19H12Cl2O3 MW(分子量)： 359.202
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	[4-(3，5-dichlorophenyl)-3，5-dihydroxy-phenyl]-phenyl-methanone
英文别名	SMM-189; SMM 189; SMM189.
CAS号	1054451-07-8
SMILES	O=C(C1=CC(O)=C(C2=CC(Cl)=CC(Cl)=C2)C(O)=C1)C3=CC=CC=C3
Inchi	InChI=1S/C19H12Cl2O3/c20-14-6-12(7-15(21)10-14)18-16(22)8-13(9-17(18)23)19(24)11-4-2-1-3-5-11/h1-10,22-23H
InchiKey	CRNLOOZHRPDURJ-UHFFFAOYSA-N
分子式 Formula	C19H12Cl2O3
分子量 Molecular Weight	359.202
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SMM-189(CAS:1054451-07-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SMM-189 is a potent and selective CB2 inverse agonist, which acts as a noncompetitive inhibitor of CP 55,940. The ability of SMM-189 to regulate microglial activation, in terms of chemokine expression and cell morphology, has been determined. SMM-189 possesses acceptable biopharmaceutical properties. Cannabinoid receptor 2 agonists and inverse agonists are emerging as new therapeutic options for a spectrum of autoimmune-related disease. Of particular interest, is the ability of CB2 ligands to regulate microglia function in neurodegenerative diseases and traumatic brain injury.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bu W, Ren H, Deng Y, Del Mar N, Guley NM, Moore BM, Honig MG, Reiner A. Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist. Front Neurosci. 2016 Oct 6;10:449. PubMed PMID: 27766068; PubMed Central PMCID: PMC5052277.

[2]Presley C, Abidi A, Suryawanshi S, Mustafa S, Meibohm B, Moore BM. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Pharmacol Res Perspect. 2015 Aug;3(4):e00159. doi: 10.1002/prp2.159. PubMed PMID: 26196013; PubMed Central PMCID: PMC4506688.

[3] Reiner A, Heldt SA, Presley CS, Guley NH, Elberger AJ, Deng Y, D'Surney L, Rogers JT, Ferrell J, Bu W, Del Mar N, Honig MG, Gurley SN, Moore BM 2nd. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. Int J Mol Sci. 2014 Dec 31;16(1):758-87. doi: 10.3390/ijms16010758. PubMed PMID: 25561230; PubMed Central PMCID: PMC4307274.

[4] Bhattacharjee H, Gurley SN, Moore BM 2nd. Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1691-3. doi: 10.1016/j.bmcl.2009.01.100. PubMed PMID: 19230659.

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