863126-95-8|Salinosporamide B|(1R,4R,5S)-1-(((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione|-范德生物科技公司

Salinosporamide B

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names：
(1R,4R,5S)-1-(((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
CAS号：
863126-95-8
MDL Number：
MF(分子式)： C15H21NO4 MW(分子量)： 279.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(1R,4R,5S)-1-(((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
英文别名	Salinosporamide B;
CAS号	863126-95-8
Inchi	InChI=1S/C15H21NO4/c1-3-10-12(18)16-15(13(19)20-14(10,15)2)11(17)9-7-5-4-6-8-9/h5,7,9-11,17H,3-4,6,8H2,1-2H3,(H,16,18)/t9-,10+,11?,14+,15+/m1/s1
InchiKey	SCJZQKFFYIGMCI-BOZRLRFCSA-N
分子式 Formula	C15H21NO4
分子量 Molecular Weight	279.33
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Salinosporamide B(CAS:863126-95-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Salinosporamide B is a deschloro analog isolated from the marine Actinomycete Salinispora tropica.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Beer LL, Moore BS. Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org Lett. 2007 Mar 1;9(5):845-8. Epub 2007 Feb 3. PubMed PMID: 17274624.

[2]Dineshkumar K, Vasudevan A, Hopper W. Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica. Comb Chem High Throughput Screen. 2017;20(1):3-19. doi: 10.2174/1386207319666161215154128. PubMed PMID: 28000560.

[3] Manam RR, Macherla VR, Tsueng G, Dring CW, Weiss J, Neuteboom ST, Lam KS, Potts BC. Antiprotealide is a natural product. J Nat Prod. 2009 Feb 27;72(2):295-7. doi: 10.1021/np800578e. PubMed PMID: 19133779.

[4] Tsueng G, McArthur KA, Potts BC, Lam KS. Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins. Appl Microbiol Biotechnol. 2007 Jul;75(5):999-1005. Epub 2007 Mar 6. PubMed PMID: 17340108.

[5] Williams PG, Buchanan GO, Feling RH, Kauffman CA, Jensen PR, Fenical W. New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. J Org Chem. 2005 Aug 5;70(16):6196-203. PubMed PMID: 16050677.

6: Reed KA, Manam RR, Mitchell SS, Xu J, Teisan S, Chao TH, Deyanat-Yazdi G, Neuteboom ST, Lam KS, Potts BC. Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. J Nat Prod. 2007 Feb;70(2):269-76. Epub 2007 Jan 23. PubMed PMID: 17243724.7: Tsueng G, Lam KS. A low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184. Appl Microbiol Biotechnol. 2008 Apr;78(5):821-6. doi: 10.1007/s00253-008-1357-x. Epub 2008 Feb 1. PubMed PMID: 18239916.8: Eustáquio AS, Moore BS. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl. 2008;47(21):3936-8. doi: 10.1002/anie.200800177. PubMed PMID: 18407559.9: Tsueng G, Sing Lam K. Effect of cobalt and vitamin B12 on the production of salinosporamides by Salinispora tropica. J Antibiot (Tokyo). 2009 Apr;62(4):213-6. doi: 10.1038/ja.2009.7. Epub 2009 Feb 6. PubMed PMID: 19198638.

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