863126-95-8|Salinosporamide B|(1R,4R,5S)-1-(((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione|-范德生物科技公司

Salinosporamide B

NMR下载 COA and HPLC MSDS下载
names：
(1R,4R,5S)-1-(((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
CAS号：
863126-95-8
MDL Number：
MF(分子式)： C15H21NO4 MW(分子量)： 279.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(1R,4R,5S)-1-(((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
英文别名	Salinosporamide B;
CAS号	863126-95-8
SMILES	O=C([C@H](CC)[C@]1(C)O2)N[C@@]1(C([C@@H]3C=CCCC3)O)C2=O
Inchi	InChI=1S/C15H21NO4/c1-3-10-12(18)16-15(13(19)20-14(10,15)2)11(17)9-7-5-4-6-8-9/h5,7,9-11,17H,3-4,6,8H2,1-2H3,(H,16,18)/t9-,10+,11?,14+,15+/m1/s1
InchiKey	SCJZQKFFYIGMCI-BOZRLRFCSA-N
分子式 Formula	C15H21NO4
分子量 Molecular Weight	279.33
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Salinosporamide B(CAS:863126-95-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Salinosporamide B is a deschloro analog isolated from the marine Actinomycete Salinispora tropica.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Beer LL, Moore BS. Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org Lett. 2007 Mar 1;9(5):845-8. Epub 2007 Feb 3. PubMed PMID: 17274624.

[2]Dineshkumar K, Vasudevan A, Hopper W. Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica. Comb Chem High Throughput Screen. 2017;20(1):3-19. doi: 10.2174/1386207319666161215154128. PubMed PMID: 28000560.

[3] Manam RR, Macherla VR, Tsueng G, Dring CW, Weiss J, Neuteboom ST, Lam KS, Potts BC. Antiprotealide is a natural product. J Nat Prod. 2009 Feb 27;72(2):295-7. doi: 10.1021/np800578e. PubMed PMID: 19133779.

[4] Tsueng G, McArthur KA, Potts BC, Lam KS. Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins. Appl Microbiol Biotechnol. 2007 Jul;75(5):999-1005. Epub 2007 Mar 6. PubMed PMID: 17340108.

[5] Williams PG, Buchanan GO, Feling RH, Kauffman CA, Jensen PR, Fenical W. New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. J Org Chem. 2005 Aug 5;70(16):6196-203. PubMed PMID: 16050677.

6: Reed KA, Manam RR, Mitchell SS, Xu J, Teisan S, Chao TH, Deyanat-Yazdi G, Neuteboom ST, Lam KS, Potts BC. Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. J Nat Prod. 2007 Feb;70(2):269-76. Epub 2007 Jan 23. PubMed PMID: 17243724.7: Tsueng G, Lam KS. A low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184. Appl Microbiol Biotechnol. 2008 Apr;78(5):821-6. doi: 10.1007/s00253-008-1357-x. Epub 2008 Feb 1. PubMed PMID: 18239916.8: Eustáquio AS, Moore BS. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl. 2008;47(21):3936-8. doi: 10.1002/anie.200800177. PubMed PMID: 18407559.9: Tsueng G, Sing Lam K. Effect of cobalt and vitamin B12 on the production of salinosporamides by Salinispora tropica. J Antibiot (Tokyo). 2009 Apr;62(4):213-6. doi: 10.1038/ja.2009.7. Epub 2009 Feb 6. PubMed PMID: 19198638.

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