86413-75-4|Sakyomicin A|(2R,3S,4aR,12bS)-2,3,4a,8-tetrahydroxy-12b-(((5R,6R)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3-methyl-3,4,4a,12b-tetrahydrotetraphene-1,7,12(2H)-trione|-范德生物科技公司

Sakyomicin A

NMR下载 COA and HPLC MSDS下载
names：
(2R,3S,4aR,12bS)-2,3,4a,8-tetrahydroxy-12b-(((5R,6R)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3-methyl-3,4,4a,12b-tetrahydrotetraphene-1,7,12(2H)-trione
CAS号：
86413-75-4
MDL Number：
MF(分子式)： C25H26O10 MW(分子量)： 486.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2R,3S,4aR,12bS)-2,3,4a,8-tetrahydroxy-12b-(((5R,6R)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3-methyl-3,4,4a,12b-tetrahydrotetraphene-1,7,12(2H)-trione
英文别名	Sakyomicin A;
CAS号	86413-75-4
SMILES	O=C1[C@H](O)[C@@](C)(O)C[C@]2(O)[C@@]1(OC3CC[C@@H](O)[C@@H](C)O3)C4=C(C(C5=C(C4=O)C=CC=C5O)=O)C=C2
Inchi	InChI=1S/C25H26O10/c1-11-14(26)6-7-16(34-11)35-25-18-13(19(28)17-12(20(18)29)4-3-5-15(17)27)8-9-24(25,33)10-23(2,32)21(30)22(25)31/h3-5,8-9,11,14,16,21,26-27,30,32-33H,6-7,10H2,1-2H3/t11-,14-,16?,21+,23+,24+,25-/m1/s1
InchiKey	CKZNKYSWWCSICZ-ZDPMPSPESA-N
分子式 Formula	C25H26O10
分子量 Molecular Weight	486.47
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sakyomicin A(CAS:86413-75-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sakyomicin A is an inhibitor of reverse transcriptase.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Take Y, Sawada M, Kunai H, Inouye Y, Nakamura S. Role of the naphthoquinone moiety in the biological activities of sakyomicin A. J Antibiot (Tokyo). 1986 Apr;39(4):557-63. PubMed PMID: 2423491.

[2]Tanaka N, Okabe T, Tanaka N, Take Y, Inouye Y, Nakamura S, Nakashima H, Yamamoto N. Inhibition by sakyomicin A of avian myeloblastosis virus reverse transcriptase and proliferation of AIDS-associated virus (HTLV-III/LAV). Jpn J Cancer Res. 1986 Apr;77(4):324-6. PubMed PMID: 2422146.

[3] Inouye Y, Okada H, Uno J, Arai T, Nakamura S. Effects of streptonigrin derivatives and sakyomicin A on the respiration of isolated rat liver mitochondria. J Antibiot (Tokyo). 1986 Apr;39(4):550-6. PubMed PMID: 2872195.

[4] Nagasawa T, Fukao H, Irie H, Yamada H. Sakyomicins A, B, C and D: new quinone-type antibiotics produced by a strain of Nocardia. Taxonomy, production, isolation and biological properties. J Antibiot (Tokyo). 1984 Jul;37(7):693-9. PubMed PMID: 6547943.

[5] Inouye Y, Oogose K, Take Y, Kubo T, Nakamura S. Role of single-electron reduction potential in inhibition of reverse transcriptase by streptonigrin and sakyomicin A. J Antibiot (Tokyo). 1987 May;40(5):702-5. PubMed PMID: 2440841.

6: Take Y, Inouye Y, Nakamura S, Allaudeen HS, Kubo A. Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases. J Antibiot (Tokyo). 1989 Jan;42(1):107-15. PubMed PMID: 2466028.7: Hafuri Y, Takemori E, Oogose K, Inouye Y, Nakamura S, Kitahara Y, Nakahara S, Kubo A. Mechanism of inhibition of reverse transcriptase by quinone antibiotics. II. Dependence on putative quinone pocket on the enzyme molecule. J Antibiot (Tokyo). 1988 Oct;41(10):1471-8. PubMed PMID: 2461354.

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