200398-40-9|S18327|1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one|-范德生物科技公司

S18327

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names：
1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one
CAS号：
200398-40-9
MDL Number：
MF(分子式)： C23H25FN4O2 MW(分子量)： 408.48
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one
英文别名	S-18327; S 18327; S18327
CAS号	200398-40-9
SMILES	O=C1N(C2=CC=CC=C2)CCN1CCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3
Inchi	InChI=1S/C23H25FN4O2/c24-18-6-7-20-21(16-18)30-25-22(20)17-8-10-26(11-9-17)12-13-27-14-15-28(23(27)29)19-4-2-1-3-5-19/h1-7,16-17H,8-15H2
InchiKey	ULCAXFRFGIKHRG-UHFFFAOYSA-N
分子式 Formula	C23H25FN4O2
分子量 Molecular Weight	408.48
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	S18327(CAS:200398-40-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	S18327 is a potential antipsychotic displaying marked antagonist properties at α1- and α2-adrenergic receptors.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Parker TJ, Della Pasqua OE, Loizillon E, Chezaubernard C, Jochemsen R, Danhof M. Pharmacokinetic-pharmacodynamic modelling in the early development phase of anti-psychotics: a comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats. Br J Pharmacol. 2001 Jan;132(1):151-8. PubMed PMID: 11156572; PubMed Central PMCID: PMC1572549.

[2]Millan MJ, Brocco M, Rivet JM, Audinot V, Newman-Tancredi A, Maiofiss L, Queriaux S, Despaux N, Peglion JL, Dekeyne A. S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multiparametric comparison with haloperidol, clozapine, and 11 other antipsychotic agents. J Pharmacol Exp Ther. 2000 Jan;292(1):54-66. PubMed PMID: 10604931.

[3] Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Adhumeau A, Brocco M, Nicolas JP, Boutin JA, Despaux N, Peglion JL. S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: I. Receptorial, neurochemical, and electrophysiological profile. J Pharmacol Exp Ther. 2000 Jan;292(1):38-53. PubMed PMID: 10604930.

[4] Dekeyne A, Iob L, Millan MJ. Generalization of clozapine as compared to other antipsychotic agents to a discriminative stimulus elicited by the serotonin (5-HT)2A antagonist, MDL100,907. Neuropharmacology. 2003 Apr;44(5):604-15. PubMed PMID: 12668046.

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