126320-77-2|R 82150|(S)-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione|-范德生物科技公司

R 82150

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names：
(S)-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione
CAS号：
126320-77-2
MDL Number：
MF(分子式)： C16H21N3S MW(分子量)： 287.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione
英文别名	R 82150; R-82150; R82150;
CAS号	126320-77-2
SMILES	C/C(C)=C\CN1[C@@H](C)Cn2c3c(cccc3C1)[nH]c2=S
Inchi	InChI=1S/C16H21N3S/c1-11(2)7-8-18-10-13-5-4-6-14-15(13)19(9-12(18)3)16(20)17-14/h4-7,12H,8-10H2,1-3H3,(H,17,20)/t12-/m0/s1
InchiKey	WTTIBCHOELPGFK-LBPRGKRZSA-N
分子式 Formula	C16H21N3S
分子量 Molecular Weight	287.42
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	R 82150(CAS:126320-77-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	R 82150 is an antiviral drug and a member of the tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepin-2(1H)-thione family of compound.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Balzarini J, Pérez-Pérez MJ, San-Félix A, Camarasa MJ, Bathurst IC, Barr PJ, De Clercq E. Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T). J Biol Chem. 1992 Jun 15;267(17):11831-8. PubMed PMID: 1376314.

[2]Debyser Z, Vandamme AM, Pauwels R, Baba M, Desmyter J, De Clercq E. Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. J Biol Chem. 1992 Jun 15;267(17):11769-76. PubMed PMID: 1376311.

[3] Debyser Z, Pauwels R, Andries K, De Clercq E. Specific HIV-1 reverse transcriptase inhibitors. J Enzyme Inhib. 1992;6(1):47-53. Review. PubMed PMID: 1285302.

[4] Frank KB, Noll GJ, Connell EV, Sim IS. Kinetic interaction of human immunodeficiency virus type 1 reverse transcriptase with the antiviral tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepine-2-(1H)-thione compound, R82150. J Biol Chem. 1991 Aug 5;266(22):14232-6. PubMed PMID: 1713579.

[5] Busso M, Resnick L. Development of an assay that detects transcriptionally competent human immunodeficiency virus type one particles. J Virol Methods. 1994 Apr;47(1-2):129-39. PubMed PMID: 7519626.

6: Pauwels R, Andries K, Desmyter J, Schols D, Kukla MJ, Breslin HJ, Raeymaeckers A, Van Gelder J, Woestenborghs R, Heykants J, et al. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature. 1990 Feb 1;343(6257):470-4. PubMed PMID: 1689015.7: Two more attacks on HIV. Lancet. 1990 Feb 10;335(8685):345. PubMed PMID: 1967781.8: Debyser Z, Pauwels R, Andries K, Desmyter J, Engelborghs Y, Janssen PA, De Clercq E. Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds. Mol Pharmacol. 1992 Jan;41(1):203-8. PubMed PMID: 1370707.9: Debyser Z, Pauwels R, Baba M, Desmyter J, De Clercq E. Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase. Mol Pharmacol. 1992 May;41(5):963-8. PubMed PMID: 1375320.10: Jonckheere H, De Vreese K, Debyser Z, Vandekerckhove J, Balzarini J, Desmyter J, De Clercq E, Anné J. A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. J Virol Methods. 1996 Sep;61(1-2):113-25. PubMed PMID: 8882944.1

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