100241-46-1|R 61837|3-methoxy-6-(4-(m-tolyl)piperazin-1-yl)pyridazine|-范德生物科技公司

R 61837

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names：
3-methoxy-6-(4-(m-tolyl)piperazin-1-yl)pyridazine
CAS号：
100241-46-1
MDL Number：
MF(分子式)： C16H20N4O MW(分子量)： 284.36
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3-methoxy-6-(4-(m-tolyl)piperazin-1-yl)pyridazine
英文别名	R 61837; R-61837; R61837;
CAS号	100241-46-1
Inchi	InChI=1S/C16H20N4O/c1-13-4-3-5-14(12-13)19-8-10-20(11-9-19)15-6-7-16(21-2)18-17-15/h3-7,12H,8-11H2,1-2H3
InchiKey	DDOAUTHWSCUHQA-UHFFFAOYSA-N
分子式 Formula	C16H20N4O
分子量 Molecular Weight	284.36
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	R 61837(CAS:100241-46-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	R 61837 is an antirhinoviral agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Andries K, Dewindt B, Snoeks J, Willebrords R, van Eemeren K, Stokbroekx R, Janssen PA. In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother. 1992 Jan;36(1):100-7. PubMed PMID: 1317142; PubMed Central PMCID: PMC189235.

[2]Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K. Human rhinovirus 14 complexed with antiviral compound R 61837. J Mol Biol. 1991 Feb 5;217(3):455-63. PubMed PMID: 1847215.

[3] Andries K, Dewindt B, De Brabander M, Stokbroekx R, Janssen PA. In vitro activity of R 61837, a new antirhinovirus compound. Arch Virol. 1988;101(3-4):155-67. PubMed PMID: 2845889.

[4] Dewindt B, van Eemeren K, Andries K. Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral Res. 1994 Sep;25(1):67-72. PubMed PMID: 7811059.

[5] Moeremans M, De Raeymaeker M, Daneels G, De Brabander M, Aerts F, Janssen C, Andries K. Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound. Antimicrob Agents Chemother. 1992 Feb;36(2):417-24. PubMed PMID: 1318682; PubMed Central PMCID: PMC188450.

6: Andries K, Dewindt B, Snoeks J, Willebrords R. Lack of quantitative correlation between inhibition of replication of rhinoviruses by an antiviral drug and their stabilization. Arch Virol. 1989;106(1-2):51-61. PubMed PMID: 2548460.7: Kim KH, Willingmann P, Gong ZX, Kremer MJ, Chapman MS, Minor I, Oliveira MA, Rossmann MG, Andries K, Diana GD, et al. A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A. J Mol Biol. 1993 Mar 5;230(1):206-27. PubMed PMID: 8383771.8: Oren DA, Zhang A, Nesvadba H, Rosenwirth B, Arnold E. Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14. J Mol Biol. 1996 May 31;259(1):120-34. PubMed PMID: 8648640.9: Dearden C, al-Nakib W, Andries K, Woestenborghs R, Tyrrell DA. Drug resistant rhinoviruses from the nose of experimentally treated volunteers. Arch Virol. 1989;109(1-2):71-81. PubMed PMID: 2558631.10: al-Nakib W, Higgins PG, Barrow GI, Tyrrell DA, Andries K, Vanden Bussche G, Taylor N, Janssen PA. Suppression of colds in human volunteers challenged with rhinovirus by a new synthetic drug (R61837). Antimicrob Agents Chemother. 1989 Apr;33(4):522-5. PubMed PMID: 2543283; PubMed Central PMCID: PMC172472.

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