111149-87-2|Luffariellolide|2(5H)-Furanone, 4-(4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl)-5-hydroxy-, (E,E)-|-范德生物科技公司

Luffariellolide

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names：
2(5H)-Furanone, 4-(4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl)-5-hydroxy-, (E,E)-
CAS号：
111149-87-2
MDL Number：
MF(分子式)： C25H38O3 MW(分子量)： 386.576
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Luffariellolide
英文别名	Luffariellolide
CAS号	111149-87-2
SMILES	O=C1OC(O)C(CC/C=C(C)/CC/C=C(C)/CCC2=C(C)CCCC2(C)C)=C1
Inchi	InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InchiKey	JPWPYTMXSXYUPG-QZPYEDBESA-N
分子式 Formula	C25H38O3
分子量 Molecular Weight	386.576
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Luffariellolide(CAS:111149-87-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Luffariellolide is a partially reversible phospholipase A2 inhibitor; a major metabolite of the sponge Luffariella.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]McEwan IJ. What lies beneath: natural products from marine organisms as nuclear receptor modulators. Biochem J. 2012 Aug 15;446(1):e1-3. doi: 10.1042/BJ20121018. PubMed PMID: 22835216.

[3] Wang S, Wang Z, Lin S, Zheng W, Wang R, Jin S, Chen J, Jin L, Li Y. Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem J. 2012 Aug 15;446(1):79-87. doi: 10.1042/BJ20120726. PubMed PMID: 22642567.

[4] Cao S, Foster C, Lazo JS, Kingston DG. Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B. Bioorg Med Chem. 2005 Sep 1;13(17):5094-8. PubMed PMID: 15927472.

[5] Elkhayat E, Edrada R, Ebel R, Wray V, van Soest R, Wiryowidagdo S, Mohamed MH, Müller WE, Proksch P. New luffariellolide derivatives from the Indonesian sponge Acanthodendrilla sp. J Nat Prod. 2004 Nov;67(11):1809-17. PubMed PMID: 15568767.

6: Froldi G, Galzignato G, Zanetti M, Montopoli M, Dorigo P, Caparrotta L. Are prostanoids related to positive inotropism by UTP and ATP? Pharmacology. 2005 Mar;73(3):140-5. Epub 2004 Nov 24. PubMed PMID: 15564788.7: Glaser KB, Sung ML, Hartman DA, Lock YW, Bauer J, Walter T, Carlson RP. Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. Skin Pharmacol. 1995;8(6):300-8. PubMed PMID: 8688196.8: Marshall LA, Murphy J, Marinari L, Chang J. Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis. Agents Actions. 1992 Sep;37(1-2):60-9. PubMed PMID: 1456181.9: Mann J. Natural products. Sponges to wipe away pain. Nature. 1992 Aug 13;358(6387):540. PubMed PMID: 1501709.10: Glaser KB, Lock YW, Chang JY. PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase. Agents Actions. 1991 Sep;34(1-2):89-92. PubMed PMID: 1665306.1

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