36149-87-8|Ludartin|Oxireno(2,3)azuleno(4,5-b)furan-2(3H)-one, 3a,4,5,7,7a,8a,8b,8c-octahydro-6,8a-dimethyl-3-methylene-, (3aS,7aR,8aS,8bS,8cS)-|-范德生物科技公司

Ludartin

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names：
Oxireno(2,3)azuleno(4,5-b)furan-2(3H)-one, 3a,4,5,7,7a,8a,8b,8c-octahydro-6,8a-dimethyl-3-methylene-, (3aS,7aR,8aS,8bS,8cS)-
CAS号：
36149-87-8
MDL Number：
MF(分子式)： C15H18O3 MW(分子量)： 246.306
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Ludartin
英文别名	Ludartin
CAS号	36149-87-8
SMILES	O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3C[C@](O4)([H])[C@]4(C)[C@@]31[H])C2=C
Inchi	InChI=1S/C15H18O3/c1-7-4-5-9-8(2)14(16)17-13(9)12-10(7)6-11-15(12,3)18-11/h9,11-13H,2,4-6H2,1,3H3/t9-,11+,12-,13-,15+/m0/s1
InchiKey	QXJYIGSXUBOSID-JZEMPJKHSA-N
分子式 Formula	C15H18O3
分子量 Molecular Weight	246.306
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ludartin(CAS:36149-87-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ludartin is a TRPA1 channel activator that has been found to produce anticancer effects by inducing DNA damage and a reduction of mitochondrial membrane potential.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lone SH, Bhat KA, Majeed R, Hamid A, Khuroo MA. Click chemistry inspired facile synthesis and bioevaluation of novel triazolyl analogs of Ludartin. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1047-5[1]doi: 10.1016/j.bmcl.2014.01.018. Epub 2014 Jan 15. PubMed PMID: 24484897.

[2]Lone SH, Bhat KA, Shakeel-u-Rehman, Majeed R, Hamid A, Khuroo MA. Synthesis and biological evaluation of amino analogs of Ludartin: potent and selective cytotoxic agents. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4931-4. doi: 10.1016/j.bmcl.2013.06.068. Epub 2013 Jul 4. PubMed PMID: 23886685.

[3] Zeng YT, Jiang JM, Lao HY, Guo JW, Lun YN, Yang M. Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica. Mol Med Rep. 2015 Mar;11(3):2234-40. doi: 10.3892/mmr.2014.3012. Epub 2014 Nov 27. PubMed PMID: 25434991.

[4] Lone SH, Bhat KA, Naseer S, Rather RA, Khuroo MA, Tasduq SA. Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Artemisia amygdalina Decne. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 1;940:135-41. doi: 10.1016/j.jchromb.2013.09.027. Epub 2013 Sep 27. PubMed PMID: 24148842.

[5] Gil RR, Gayathri C, Tsarevsky NV, Matyjaszewski K. Stretched poly(methyl methacrylate) gel aligns small organic molecules in chloroform. stereochemical analysis and diastereotopic proton NMR assignment in ludartin using residual dipolar couplings and 3J coupling constant analysis. J Org Chem. 2008 Feb 1;73(3):840-8. doi: 10.1021/jo701871g. Epub 2008 Jan 5. PubMed PMID: 18177050.

6: Giordano OS, Guerreiro E, Pestchanker MJ, Guzman J, Pastor D, Guardia T. The gastric cytoprotective effect of several sesquiterpene lactones. J Nat Prod. 1990 Jul-Aug;53(4):803-9. PubMed PMID: 2095374.7: Zhang SL, Li BL, Li W, Lu M, Ni LY, Ma HL, Meng QG. The Effects of Ludartin on Cell Proliferation, Cell Migration, Cell Cycle Arrest and Apoptosis Are Associated with Upregulation of p21WAF1 in Saos-2 Osteosarcoma Cells In Vitro. Med Sci Monit. 2018 Jul 16;2

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