150985-54-9|LSL-60101|2-(2-Benzofuranyl)-1H-imidazole|-范德生物科技公司

LSL-60101

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names：
2-(2-Benzofuranyl)-1H-imidazole
CAS号：
150985-54-9
MDL Number：
MF(分子式)： C11H8N2O MW(分子量)： 184.198
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	LSL-60101
英文别名	LSL60101; LSL-60101; LSL 60101;
CAS号	150985-54-9
SMILES	C1(C2=CC3=CC=CC=C3O2)=NC=CN1
Inchi	InChI=1S/C11H8N2O/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11/h1-7H,(H,12,13)
InchiKey	VBFQIUOSXHUWCT-UHFFFAOYSA-N
分子式 Formula	C11H8N2O
分子量 Molecular Weight	184.198
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	LSL-60101(CAS:150985-54-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	LSL60101 is a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Garau C, Miralles A, García-Sevilla JA. Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain. J Psychopharmacol. 2013 Feb;27(2):123-34. doi: 10.1177/0269881112450785. Epub 2012 Jun 20. PMID: 22719017.

[2]Miralles A, Esteban S, Sastre-Coll A, Moranta D, Asensio VJ, García-Sevilla JA. High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. Eur J Pharmacol. 2005 Aug 22;518(2-3):234-42. doi: 10.1016/j.ejphar.2005.06.023. PMID: 16061219.

[3] Casanovas A, Olmos G, Ribera J, Boronat MA, Esquerda JE, García-Sevilla JA. Induction of reactive astrocytosis and prevention of motoneuron cell death by the I(2)-imidazoline receptor ligand LSL 60101. Br J Pharmacol. 2000 Aug;130(8):1767-76. doi: 10.1038/sj.bjp.0703485. PMID: 10952664; PMCID: PMC1572252.

[4] Sánchez-Blázquez P, Boronat MA, Olmos G, García-Sevilla JA, Garzón J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000 May;130(1):146-52. doi: 10.1038/sj.bjp.0703294. PMID: 10781010; PMCID: PMC1572044.

[5] Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, Gasull T, Assumpció Boronat M, Trullas R, Villarroel A, Lerma J, García-Sevilla JA. Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor. Br J Pharmacol. 1999 Jul;127(6):1317-26. doi: 10.1038/sj.bjp.0702679. PMID: 10455281; PMCID: PMC1760666.

6: Escribá PV, Ozaita A, García-Sevilla JA. Pharmacologic characterization of imidazoline receptor proteins identified by immunologic techniques and other methods. Ann N Y Acad Sci. 1999 Jun 21;881:8-25. doi: 10.1111/j.1749-6632.1999.tb09336.x. PMID: 10415892.7: Boronat MA, Olmos G, García-Sevilla JA. Attenuation of tolerance to opioid- induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands. Br J Pharmacol. 1998 Sep;125(1):175-85. doi: 10.1038/sj.bjp.0702031. PMID: 9776358; PMCID: PMC1565592.8: Ozaita A, Olmos G, Boronat MA, Lizcano JM, Unzeta M, García-Sevilla JA. Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liver. Br J Pharmacol. 1997 Jul;121(5):901-12. doi: 10.1038/sj.bjp.0701214. PMID: 9222546; PMCID: PMC1564771.9: Hosseini AR, King PR, Louis WJ, Gundlach AL. [3H]2-(2-Benzofuranyl)-2-imidazoline, a highly selective radioligand for I2-imidazoline receptor binding sites. Studies in rabbit kidney membranes. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):131-8. doi: 10.1007/pl00004911. PMID: 9007853.10: Escribá PV, Alemany R, Sastre M, Olmos G, Ozaita A, García-Sevilla JA. Pharmacological modulation of immunoreactive imidazoline receptor proteins in rat brain: relationship with non-adrenoceptor [3H]-idazoxan binding sites. Br J Pharmacol. 1996 Aug;118(8):2029-36. doi: 10.1111/j.1476-5381.1996.tb15640.x. PMID: 8864539; PMCID: PMC1909863.1

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