1185410-60-9|LRH-1 Inhibitor-3|1-[3'-[1-[2-(4-Morpholinyl)ethyl]-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]-ethanone|-范德生物科技公司

LRH-1 Inhibitor-3

NMR下载 COA and HPLC MSDS下载
names：
1-[3'-[1-[2-(4-Morpholinyl)ethyl]-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]-ethanone
CAS号：
1185410-60-9
MDL Number：
MF(分子式)： C23H25N3O2 MW(分子量)： 375.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	LRH-1 Inhibitor-3
英文别名	LRH-1 Inhibitor-3; LRH-1-Inhibitor-3; LRH1 Inhibitor 3; LRH 1 Inhibitor 3;
CAS号	1185410-60-9
SMILES	CC(C1=CC(C2=CC=CC(C3=NN(CCN4CCOCC4)C=C3)=C2)=CC=C1)=O
Inchi	InChI=1S/C23H25N3O2/c1-18(27)19-4-2-5-20(16-19)21-6-3-7-22(17-21)23-8-9-26(24-23)11-10-25-12-14-28-15-13-25/h2-9,16-17H,10-15H2,1H3
InchiKey	SLRQICGVSRRRDI-UHFFFAOYSA-N
分子式 Formula	C23H25N3O2
分子量 Molecular Weight	375.47
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	LRH-1 Inhibitor-3(CAS:1185410-60-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	LRH-1 Inhibitor-3 is the first small molecule antagonist of LRH-1 activity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jiang Y, Zhao Y, Chen S, Chen L, Li C, Zhou X. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary. Reprod Biol Endocrinol. 2018 Mar 20;16(1):25. doi: 10.1186/s12958-018-0348-8. PubMed PMID: 29558965; PubMed Central PMCID: PMC5859637.

[2]Salmenkari H, Holappa M, Forsgard RA, Korpela R, Vapaatalo H. Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice. J Physiol Pharmacol. 2017 Jun;68(3):355-362. PubMed PMID: 28820392.

[3] Yang FM, Feng SJ, Lai TC, Hu MC. A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding. Biochem J. 2015 Oct 15;471(2):199-209. doi: 10.1042/BJ20150252. Epub 2015 Aug 12. PubMed PMID: 26268559.

[4] Bianco S, Jangal M, Garneau D, Gévry N. LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. Oncogene. 2015 Aug 20;34(34):4509-18. doi: 10.1038/onc.2014.382. Epub 2014 Dec 1. PubMed PMID: 25435372.

[5] Lai WA, Yeh YT, Lee MT, Wu LS, Ke FC, Hwang JJ. Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis. J Lipid Res. 2013 Feb;54(2):365-78. doi: 10.1194/jlr.M030239. Epub 2012 Nov 28. PubMed PMID: 23197320; PubMed Central PMCID: PMC3588866.

6: Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD. Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Mol Endocrinol. 2010 Dec;24(12):2281-91. doi: 10.1210/me.2010-0133. Epub 2010 Oct 13. PubMed PMID: 20943815; PubMed Central PMCID: PMC2999479.7: Guo J, Tao SX, Chen M, Shi YQ, Zhang ZQ, Li YC, Zhang XS, Hu ZY, Liu YX. Heat treatment induces liver receptor homolog-1 expression in monkey and rat sertoli cells. Endocrinology. 2007 Mar;148(3):1255-65. Epub 2006 Dec 14. PubMed PMID: 17170099.8: Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, Choi HS. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem. 2002 Jan 18;277(3):1739-48. Epub 2001 Nov 8. PubMed PMID: 11705994.

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