170902-34-8|Longicin|(S)-5-methyl-3-((2R,8R,11R)-2,8,11-trihydroxy-11-((2R,5R)-5-((S)-1-hydroxypentadecyl)tetrahydrofuran-2-yl)undecyl)furan-2(5H)-one|-范德生物科技公司

Longicin

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names：
(S)-5-methyl-3-((2R,8R,11R)-2,8,11-trihydroxy-11-((2R,5R)-5-((S)-1-hydroxypentadecyl)tetrahydrofuran-2-yl)undecyl)furan-2(5H)-one
CAS号：
170902-34-8
MDL Number：
MF(分子式)： C35H64O7 MW(分子量)： 596.89
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Longicin
英文别名	Longicin;
CAS号	170902-34-8
Inchi	InChI=1S/C35H64O7/c1-3-4-5-6-7-8-9-10-11-12-13-17-20-31(38)33-23-24-34(42-33)32(39)22-21-29(36)18-15-14-16-19-30(37)26-28-25-27(2)41-35(28)40/h25,27,29-34,36-39H,3-24,26H2,1-2H3/t27-,29+,30+,31-,32+,33+,34+/m0/s1
InchiKey	NBVJDUCRUAUMAA-ZDTLKTIVSA-N
分子式 Formula	C35H64O7
分子量 Molecular Weight	596.89
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Longicin(CAS:170902-34-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Longicin is a cytotoxic agent isolated from Asimina longifolia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Talactac MR, Yoshii K, Maeda H, Kusakisako K, Hernandez EP, Tsuji N, Fujisaki K, Galay RL, Tanaka T, Mochizuki M. Virucidal activity of Haemaphysalis longicornis longicin P4 peptide against tick-borne encephalitis virus surrogate Langat virus. Parasit Vectors. 2016 Feb 2;9:59. doi: 10.1186/s13071-016-1344-5. PubMed PMID: 26830840; PubMed Central PMCID: PMC4736483.

[2]Tanaka T, Maeda H, Matsuo T, Boldbattar D, Umemiya-Shirafuji R, Kume A, Suzuki H, Xuan X, Tsuji N, Fujisaki K. Parasiticidal activity of Haemaphysalis longicornis longicin P4 peptide against Toxoplasma gondii. Peptides. 2012 Mar;34(1):242-50. doi: 10.1016/j.peptides.2011.07.027. Epub 2011 Aug 9. PubMed PMID: 21849158.

[3] Tsuji N, Battsetseg B, Boldbaatar D, Miyoshi T, Xuan X, Oliver JH Jr, Fujisaki K. Babesial vector tick defensin against Babesia sp. parasites. Infect Immun. 2007 Jul;75(7):3633-40. Epub 2007 May 7. PubMed PMID: 17485458; PubMed Central PMCID: PMC1932947.

[4] Galay RL, Maeda H, Aung KM, Umemiya-Shirafuji R, Xuan X, Igarashi I, Tsuji N, Tanaka T, Fujisaki K. Anti-babesial activity of a potent peptide fragment derived from longicin of Haemaphysalis longicornis. Trop Anim Health Prod. 2012 Feb;44(2):343-8. doi: 10.1007/s11250-011-0027-7. Epub 2011 Nov 20. PubMed PMID: 22102016.

[5] Takeo T, Tanaka T, Matsubayashi M, Tsujio M, Umemiya-Shirafuji R, Tsuji N, Fujisaki K, Matsui T, Matsuo T. Evaluation of Eimeria krijgsmanni as a murine model for testing the efficacy of anti-parasitic agents. Acta Parasitol. 2015 Jun;60(2):190-5. doi: 10.1515/ap-2015-0027. PubMed PMID: 26203984.

6: Rahman M, Tsuji N, Boldbaatar D, Battur B, Liao M, Umemiya-Shirafuji R, You M, Tanaka T, Fujisaki K. Structural characterization and cytolytic activity of a potent antimicrobial motif in longicin, a defensin-like peptide in the tick Haemaphysalis longicornis. J Vet Med Sci. 2010 Feb;72(2):149-56. Epub 2009 Nov 25. PubMed PMID: 19940394.7: Ye Q, Zeng L, Zhang Y, Zhao GX, McLaughlin JL, Woo MH, Evert DR. Longicin and goniothalamicinone: novel bioactive monotetrahydrofuran acetogenins from Asimina longifolia. J Nat Prod. 1995 Sep;58(9):1398-406. PubMed PMID: 7494147.8: Hanessian S, Giroux S, Buffat M. Total synthesis and structural confirmation of (+)-longicin. Org Lett. 2005 Sep 1;7(18):3989-92. PubMed PMID: 16119949.9: Tsuji N, Fujisaki K. Longicin plays a crucial role in inhibiting the transmission of Babesia parasites in the vector tick Haemaphysalis longicornis. Future Microbiol. 2007 Dec;2(6):575-8. PubMed PMID: 18041897.10: Takechi R, Galay RL, Matsuo T, Maeda H, Kusakisako K, Talactac MR, Mochizuki M, Fujisaki K, Tanaka T. Role of the tumor necrosis factor receptor-associated factor-type zinc finger domain containing protein 1 (TRAFD1) from the hard tick Haemaphysalis longicornis in immunity against bacterial infection. Ticks Tick Borne Dis. 2016 Feb;7(1):36-45. doi: 10.1016/j.ttbdis.2015.08.002. Epub 2015 Aug 7. PubMed PMID: 26283173.

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