1703-32-8|LG 50046|2,6-dimethoxy-4-(piperidine-1-carbonyl)phenyl ethyl carbonate|-范德生物科技公司

LG 50046

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names：
2,6-dimethoxy-4-(piperidine-1-carbonyl)phenyl ethyl carbonate
CAS号：
1703-32-8
MDL Number：
MF(分子式)： C17H23NO6 MW(分子量)： 337.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	LG 50046
英文别名	LG 50046; LG-50046; LG50046; LG 50,046; LG-50,046; LG50,046;
CAS号	1703-32-8
Inchi	InChI=1S/C17H23NO6/c1-4-23-17(20)24-15-13(21-2)10-12(11-14(15)22-3)16(19)18-8-6-5-7-9-18/h10-11H,4-9H2,1-3H3
InchiKey	BRKLZMLKIKEGJW-UHFFFAOYSA-N
分子式 Formula	C17H23NO6
分子量 Molecular Weight	337.37
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	LG 50046(CAS:1703-32-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	LG 50046 is a bioactive chemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Landowski TH, Samulitis BK, Dorr RT. The diaryl oxazole PC-046 is a tubulin-binding agent with experimental anti-tumor efficacy in hematologic cancers. Invest New Drugs. 2013 Dec;31(6):1616-25. doi: 10.1007/s10637-013-0019-8. Epub 2013 Sep 14. PubMed PMID: 24037082; PubMed Central PMCID: PMC3899824.

[2]Norén T, Johansson K, Unemo M. Clostridium difficile PCR ribotype 046 is common among neonatal pigs and humans in Sweden. Clin Microbiol Infect. 2014 Jan;20(1):O2-6. doi: 10.1111/1469-0691.12296. Epub 2013 Aug 8. PubMed PMID: 23927574.

[3] Nambu F, Motoishi M, Omawari N, Okegawa T, Kawasaki A, Ikeda S. Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs. Jpn J Pharmacol. 1990 Feb;52(2):307-17. PubMed PMID: 2313938.

[4] Kato T, Hayashi K, Takamizawa K, Tsushima N. A selective thromboxane synthetase inhibitor, OKY-046, fails to improve blood rheology in endotoxin-shocked rabbits. J Anesth. 1991 Jul;5(3):247-54. PubMed PMID: 15278626.

[5] Komatsu H, Takehana Y, Kikuchi S, Kojima M, Hamano S, Kusama H, Okegawa T, Ikeda S. Effect of a thromboxane A2 synthetase inhibitor (OKY-046.HCl) on airway hyperresponsiveness in guinea pigs. Eur J Pharmacol. 1990 Aug 2;184(1):87-95. PubMed PMID: 2170151.

6: Hora K, Oguchi H, Furukawa T, Hora K, Tokunaga S. Effects of a selective thromboxane synthetase inhibitor OKY-046 on experimental diabetic nephropathy. Nephron. 1990;56(3):297-305. PubMed PMID: 2077412.7: Nagai H, Yakuo I, Togawa M, Arimura A, Matsuura N, Koda A, Hamano S, Ujiie A, Nakazawa M. Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs. Prostaglandins Leukot Med. 1987 Dec;30(2-3):111-21. PubMed PMID: 2447593.8: Hiraku S, Taniguchi K, Wakitani K, Omawari N, Kira H, Miyamoto T, Okegawa T, Kawasaki A, Ujiie A. Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn J Pharmacol. 1986 Jul;41(3):393-401. PubMed PMID: 3093741.9: Ghodgaonkar RB, Dubin NH. Effect of OKY-046, a selective thromboxane inhibitor, on prostaglandin production and function of pregnant rat uteri and platelets. Prostaglandins Leukot Med. 1987 Jan;26(1):33-46. PubMed PMID: 3468521.10: Fujimura M, Sasaki F, Nakatsumi Y, Takahashi Y, Hifumi S, Taga K, Mifune J, Tanaka T, Matsuda T. Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax. 1986 Dec;41(12):955-9. PubMed PMID: 3590057; PubMed Central PMCID: PMC460553.1

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