51473-23-5|Lergotrile mesylate|2-((6aR,9S,10aR)-5-chloro-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)acetonitrile methanesulfonate|-范德生物科技公司

Lergotrile mesylate

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names：
2-((6aR,9S,10aR)-5-chloro-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)acetonitrile methanesulfonate
CAS号：
51473-23-5
MDL Number：
MF(分子式)： C18H22ClN3O3S MW(分子量)： 395.9
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lergotrile mesylate
英文别名	Lergotrile mesylate; LY 83636; LY-83636; LY83636; 83636;
CAS号	51473-23-5
SMILES	[H][C@@]1(N(C)C[C@H](CC#N)C[C@@]12[H])CC3=C(Cl)NC4=C3C2=CC=C4.CS(=O)(O)=O
Inchi	InChI=1S/C17H18ClN3.CH4O3S/c1-21-9-10(5-6-19)7-12-11-3-2-4-14-16(11)13(8-15(12)21)17(18)20-14;1-5(2,3)4/h2-4,10,12,15,20H,5,7-9H2,1H3;1H3,(H,2,3,4)/t10-,12-,15-;/m1./s1
InchiKey	WXHDJVDIJQDJMK-AYJWUPBJSA-N
分子式 Formula	C18H22ClN3O3S
分子量 Molecular Weight	395.9
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lergotrile mesylate(CAS:51473-23-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lergotrile mesylate is an ergoline derivative that inhibits prolactin in vivo and in vitro.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sherman BM, Swanson JA, Chapler FK. The treatment of hyperprolactinemia with a new ergot derivative, lergotrile mesylate. Fertil Steril. 1978 Mar;29(3):291-5. PubMed PMID: 565303.

[2]Clemens JA, Smalstig EB, Shaar CJ. Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action. Acta Endocrinol (Copenh). 1975 Jun;79(2):230-7. PubMed PMID: 166535.

[3] Schmidt MJ. Dopamine agonist-induced hyperglycemia in rats: effects of lergotrile mesylate. Eur J Pharmacol. 1979 Oct 26;59(1-2):95-101. PubMed PMID: 41730.

[4] Lieberman A, Estey E, Kupersmith M, Gopinathan G, Goldstein M. Treatment of Parkinson's disease with lergotrile mesylate. JAMA. 1977 Nov 28;238(22):2380-2. PubMed PMID: 335094.

[5] Fuller RW, Perry KW. Effect of lergotrile on 3,4-dihydroxyphenylacetic acid (DOPAC) concentration and dopamine turnover in rat brain. J Neural Transm. 1978;42(1):23-35. PubMed PMID: 641542.

6: Thorner MO, Ryan SM, Wass JA, Jones A, Bouloux P, Williams S, Besser GM. Effect of the dopamine agonist, lergotrile mesylate, on circulating anterior pituitary hormones in man. J Clin Endocrinol Metab. 1978 Aug;47(2):372-8. PubMed PMID: 45463.7: Hooley RD, Fell LR, Findlay JK. The effect of 2-bromo-alpha-ergocryptine and 2-chloro-alpha-methylergoline-8beta-acetonitrile (lergotrile mesylate) on the prolactin secretion of the ewe. Acta Endocrinol (Copenh). 1977 Dec;86(4):722-7. PubMed PMID: 411304.8: Sinha YN, Salocks CB, VanderLaan WP. A comparison of the effects of CB-154 and lergotrile mesylate on prolactin and growth hormone secretion in mice. Horm Metab Res. 1976 Sep;8(5):332-6. PubMed PMID: 989755.9: Sved AF, Fernstrom JD. Reduction in blood pressure in normal and spontaneously hypertensive rats by lergotrile mesylate. J Pharm Pharmacol. 1979 Dec;31(12):814-7. PubMed PMID: 43364.10: Wiggins C, Wise PM, Ratner A. Differences in the response pattern of aged female rats to treatment with lergotrile mesylate. Proc Soc Exp Biol Med. 1985 Jun;179(2):173-9. PubMed PMID: 2859599.1

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