99134-29-9|L 651896|(E)-6-(3-(2-(hydroxymethyl)phenyl)allyl)-2,3-dihydrobenzofuran-5-ol|-范德生物科技公司

L 651896

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names：
(E)-6-(3-(2-(hydroxymethyl)phenyl)allyl)-2,3-dihydrobenzofuran-5-ol
CAS号：
99134-29-9
MDL Number：
MF(分子式)： C18H18O3 MW(分子量)： 282.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L 651896
英文别名	L 651896; L-651896; L651896;
CAS号	99134-29-9
SMILES	OC1=C(C/C=C/C2=CC=CC=C2CO)C=C(OCC3)C3=C1
Inchi	InChI=1S/C18H18O3/c19-12-16-5-2-1-4-13(16)6-3-7-14-11-18-15(8-9-21-18)10-17(14)20/h1-6,10-11,19-20H,7-9,12H2/b6-3+
InchiKey	RRKABGWFFMSVQH-ZZXKWVIFSA-N
分子式 Formula	C18H18O3
分子量 Molecular Weight	282.33
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 651896(CAS:99134-29-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 651896 is a 5-lipoxygenase inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Millichamp NJ, Dziezyc J, Rohde BH, Chiou GC, Smith WB. Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs. Am J Vet Res. 1991 Aug;52(8):1279-84. PubMed PMID: 1656823.

[2]Hammond ML, Zambias RA, Chang MN, Jensen NP, McDonald J, Thompson K, Boulton DA, Kopka IE, Hand KM, Opas EE, et al. Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent. J Med Chem. 1990 Mar;33(3):908-18. PubMed PMID: 2308140.

[3] Dembinska-Kiec A, Novak P, Peskar BM, Peskar BA. Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. Prog Clin Biol Res. 1989;301:487-91. PubMed PMID: 2798459.

[4] Dembinska-Kiec A, Peskar BA, Muller MK, Peskar BM. The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. Prostaglandins. 1989 Jan;37(1):69-91. PubMed PMID: 2717778.

[5] Jones TR, Charette L, Denis D. Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1988 Jun;66(6):762-8. PubMed PMID: 2844372.

6: Matuszewski BK, Constanzer ML, Bayne WF. Determination of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol in plasma using liquid chromatography with electrochemical detection. J Chromatogr. 1988 Apr 29;426(2):295-304. PubMed PMID: 3392142.7: Bonney RJ, Davies P, Dougherty H, Egan RW, Gale PH, Chang M, Hammond M, Jensen N, MacDonald J, Thompson K, et al. Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent. Biochem Pharmacol. 1987 Nov 15;36(22):3885-91. PubMed PMID: 3120729.8: Garceau D, Ford-Hutchinson AW, Charleson S. 5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig. Eur J Pharmacol. 1987 Nov 3;143(1):1-7. PubMed PMID: 2826183.9: Chan CC, Dubois L, Young V. Effects of two novel inhibitors of 5-lipoxygenase, L-651,392 and L-651,896, in a guinea-pig model of epidermal hyperproliferation. Eur J Pharmacol. 1987 Jul 2;139(1):11-8. PubMed PMID: 2820754.

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