233271-65-3|HI-236|1-(5-Bromopyridin-2-yl)-3-[2-(2,5-dimethoxyphenyl)ethyl]thiourea|-范德生物科技公司

HI-236

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names：
1-(5-Bromopyridin-2-yl)-3-[2-(2,5-dimethoxyphenyl)ethyl]thiourea
CAS号：
233271-65-3
MDL Number：
MF(分子式)： C16H18BrN3O2S MW(分子量)： 396.3
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	HI-236
英文别名	HI-236; HI 236; HI236; D-PBT; D PBT; DPBT;
CAS号	233271-65-3
Inchi	InChI=1S/C16H18BrN3O2S/c1-21-13-4-5-14(22-2)11(9-13)7-8-18-16(23)20-15-6-3-12(17)10-19-15/h3-6,9-10H,7-8H2,1-2H3,(H2,18,19,20,23)
InchiKey	GNLVRKKIIIVZHZ-UHFFFAOYSA-N
分子式 Formula	C16H18BrN3O2S
分子量 Molecular Weight	396.3
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	HI-236(CAS:233271-65-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	HI-236 is a non-nucleoside HIV-1 reverse-transcriptase inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Younis Y, Hunter R, Muhanji CI, Hale I, Singh R, Bailey CM, Sullivan TJ, Anderson KS. [d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase. Bioorg Med Chem. 2010 Jul 1;18(13):4661-73. doi: 10.1016/j.bmc.2010.05.025. Epub 2010 May 1[1]PubMed PMID: 20605472; PubMed Central PMCID: PMC2964380.

[2]Hunter R, Younis Y, Muhanji CI, Curtin TL, Naidoo KJ, Petersen M, Bailey CM, Basavapathruni A, Anderson KS. C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors. Bioorg Med Chem. 2008 Dec 15;16(24):10270-80. doi: 10.1016/j.bmc.2008.10.048. Epub 2008 Nov 1. PubMed PMID: 18996020; PubMed Central PMCID: PMC2639753.

[3] Hunter R, Muhanji CI, Hale I, Bailey CM, Basavapathruni A, Anderson KS. [d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor. Bioorg Med Chem Lett. 2007 May 1;17(9):2614-7. Epub 2007 Feb 4. PubMed PMID: 17317163.

[4] Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM. Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. PubMed PMID: 10386942.

[5] Chen CL, Venkatachalam TK, Waurzyniak B, Chelstrom L, Uckun FM. In vivo toxicity, pharmacokinetic features and tissue distribution of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase. Arzneimittelforschung. 2001;51(7):574-81. PubMed PMID: 11505789.

6: Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM. Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus. Antivir Chem Chemother. 1999 Sep;10(5):233-40. PubMed PMID: 10574178.7: D'Cruz OJ, Uckun FM. Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide. Mol Hum Reprod. 2005 Oct;11(10):767-77. Epub 2005 Oct 27. PubMed PMID: 16254003.8: D'Cruz OJ, Uckun FM. Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity. Biol Reprod. 1999 Jun;60(6):1419-28. PubMed PMID: 10330101.

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