884600-68-4|GSM-1|2-((2S,4R)-1-((R)-1-(4-chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid|-范德生物科技公司

GSM-1

NMR下载 COA and HPLC MSDS下载
names：
2-((2S,4R)-1-((R)-1-(4-chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid
CAS号：
884600-68-4
MDL Number：
MF(分子式)： C26H31ClF3NO2 MW(分子量)： 481.98
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	GSM-1
英文别名	GSM-1; GSM 1 (enzyme modulator); J2.559.799K; gamma Secretase modulator 1;
CAS号	884600-68-4
SMILES	O=C(O)C[C@H]1C[C@@H](C2=CC=C(C(F)(F)F)C=C2)N([C@@H](C3=CC=C(Cl)C=C3)CCC(C)C)CC1
Inchi	InChI=1S/C26H31ClF3NO2/c1-17(2)3-12-23(19-6-10-22(27)11-7-19)31-14-13-18(16-25(32)33)15-24(31)20-4-8-21(9-5-20)26(28,29)30/h4-11,17-18,23-24H,3,12-16H2,1-2H3,(H,32,33)/t18-,23-,24+/m1/s1
InchiKey	VMVWLAPASRQXFL-QFWMQHCXSA-N
分子式 Formula	C26H31ClF3NO2
分子量 Molecular Weight	481.98
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	GSM-1(CAS:884600-68-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	GSM-1 is a γ-Secretase modulator
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ling IF, Golde TE, Galasko DR, Koo EH. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimers Res Ther. 2015 Aug 5;7(1):55. doi: 10.1186/s13195-015-0137-y. eCollection 2015. PubMed PMID: 26244059; PubMed Central PMCID: PMC4523931.

[2]Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. J Biol Chem. 2013 Apr 5;288(14):9710-20. doi: 10.1074/jbc.M112.398602. Epub 2013 Feb 8. PubMed PMID: 23396974; PubMed Central PMCID: PMC3617273.

[3] Crump CJ, Fish BA, Castro SV, Chau DM, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li YM. Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. ACS Chem Neurosci. 2011 Dec 21;2(12):705-710. PubMed PMID: 22229075; PubMed Central PMCID: PMC3249837.

[4] Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J. 2011 Oct 14;30(23):4815-24. doi: 10.1038/emboj.2011.372. PubMed PMID: 22002539; PubMed Central PMCID: PMC3243616.

[5] Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C, Steiner H. Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. J Biol Chem. 2011 Apr 29;286(17):15240-51. doi: 10.1074/jbc.M110.213587. Epub 2011 Feb 25. PubMed PMID: 21357415; PubMed Central PMCID: PMC3083200.

6: Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators. J Biol Chem. 2010 Jun 4;285(23):17798-810. doi: 10.1074/jbc.M110.103283. Epub 2010 Mar 26. PubMed PMID: 20348104; PubMed Central PMCID: PMC2878544.

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