85666-17-7|Furegrelate|sodium;5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate|-范德生物科技公司

Furegrelate

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names：
sodium;5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate
CAS号：
85666-17-7
MDL Number：
MF(分子式)： C15H10NNaO3 MW(分子量)： 275.2388
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Furegrelate
英文别名	Furegrelate; U 63557A; U-63557A; U63557A
CAS号	85666-17-7
SMILES	O=C(C(O1)=CC2=C1C=CC(CC3=CC=CN=C3)=C2)[O-].[Na+]
Inchi	InChI=1S/C15H11NO3.Na/c17-15(18)14-8-12-7-10(3-4-13(12)19-14)6-11-2-1-5-16-9-11;/h1-5,7-9H,6H2,(H,17,18);/q;+1/p-1
InchiKey	XBTIPIZROJAKOJ-UHFFFAOYSA-M
分子式 Formula	C15H10NNaO3
分子量 Molecular Weight	275.2388
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Furegrelate(CAS:85666-17-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Furegrelate is a thromboxane synthase inhibitor that attenuates the renal vasoconstriction of angiotensin II, presumably by enhancing the formation of vasodilator prostaglandins.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Hirenallur-S DK, Detweiler ND, Haworth ST, Leming JT, Gordon JB, Rusch NJ. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200. doi: 10.4103/2045-8932.97605. PubMed PMID: 22837860; PubMed Central PMCID: PMC3401873.

[2]Pestel S, Nath A, Jungermann K, Schieferdecker HL. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. Biochem Pharmacol. 2003 Aug 15;66(4):643-52. PubMed PMID: 12906929.

[3] Kaushal RD, Wilson TW. Effect of furegrelate on renal plasma flow after angiotensin II infusion. Can J Physiol Pharmacol. 1990 Apr;68(4):500-4. PubMed PMID: 2328452.

[4] Martorell A, Sagredo A, Aras-López R, Balfagón G, Ferrer M. Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta. Cardiovasc Res. 2009 Nov 1;84(2):300-8. doi: 10.1093/cvr/cvp214. Epub 2009 Jun 30. PubMed PMID: 19567483.

[5] Mohrland JS, Vander Lugt JT, Lakings DB. Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects. Eur J Clin Pharmacol. 1990;38(5):485-8. PubMed PMID: 2379533.

6: Mohrland JS, Vander Lugt JT, Gorman RR, Lakings DB. Thromboxane synthase activity and platelet function after furegrelate administration in man. J Clin Pharmacol. 1989 Jan;29(1):53-8. PubMed PMID: 2708549.7: Payne JE, Langsfeld M, Joseph M, Huber D, Gray-Weale A, Meyer JH, Smith T, Lusby RJ. Effects of Furegrelate (Upjohn 63557A) on patency and platelet deposition after canine carotid endarterectomy. Aust N Z J Surg. 1991 Aug;61(8):619-25. PubMed PMID: 1867616.8: Addison MP, Singh TU, Parida S, Choudhury S, Kasa JK, Sukumaran SV, Darzi SA, Kandasamy K, Singh V, Kumar D, Mishra SK. NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2. Pharmacol Rep. 2016 Jun;68(3):620-6. doi: 10.1016/j.pharep.2016.01.003. Epub 2016 Jan 19. PubMed PMID: 26991376.9: Xavier FE, Blanco-Rivero J, Sastre E, Badimón L, Balfagón G. Simultaneous inhibition of TXA(2) and PGI(2) synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats. Clin Sci (Lond). 2010 Jun 25;119(7):283-92. doi: 10.1042/CS20090536. PubMed PMID: 20459396.10: Wilson TW, Badahman AH, Kaushal RD. Thromboxane synthase inhibition enhances furosemide-induced renal vasodilation. Clin Invest Med. 1993 Oct;16(5):372-8. PubMed PMID: 8261690.1

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