13877-76-4|Formycin B|3-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one|-范德生物科技公司

Formycin B

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names：
3-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS号：
13877-76-4
MDL Number：
MF(分子式)： C10H12N4O5 MW(分子量)： 268.22
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Formycin B
英文别名	Formycin B; Laurusin; Ohyamycin; NSC 106486; NSC-106486; NSC106486;
CAS号	13877-76-4
SMILES	O=C1C(NN=C2[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)=C2NC=N1
Inchi	InChI=1S/C10H12N4O5/c15-1-3-7(16)8(17)9(19-3)5-4-6(14-13-5)10(18)12-2-11-4/h2-3,7-9,15-17H,1H2,(H,13,14)(H,11,12,18)/t3-,7-,8-,9+/m1/s1
InchiKey	MTCJZZBQNCXKAP-KSYZLYKTSA-N
分子式 Formula	C10H12N4O5
分子量 Molecular Weight	268.22
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Formycin B(CAS:13877-76-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Formycin B is a model nucleoside analogue.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wu X, Hui AC, Giacomini KM. Formycin B elimination from the cerebrospinal fluid of the rat. Pharm Res. 1993 Apr;10(4):611-5. PubMed PMID: 8483848.

[2]Borgland SL, Parkinson FE. Uptake and release of [3H]formycin B via sodium-dependent nucleoside transporters in mouse leukemic L1210/MA27.1 cells. J Pharmacol Exp Ther. 1997 Apr;281(1):347-53. PubMed PMID: 9103516.

[3] Burke T, Lee S, Ferguson PJ, Hammond JR. Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. J Pharmacol Exp Ther. 1998 Sep;286(3):1333-40. PubMed PMID: 9732397.

[4] Robinson N, Kaur K, Emmett K, Iovannisci DM, Ullman B. Biochemical genetic analysis of formycin B action in Leishmania donovani. J Biol Chem. 1984 Jun 25;259(12):7637-43. PubMed PMID: 6203896.

[5] Spector T, Jones TE, LaFon SW, Nelson DJ, Berens RL, Marr JJ. Monophosphates of formycin B and allopurinol riboside. Interactions with leishmanial and mammalian succino-AMP synthetase and GMP reductase. Biochem Pharmacol. 1984 May 15;33(10):1611-7. PubMed PMID: 6732835.

6: Berman JD, Rainey P, Santi DV. Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages. J Exp Med. 1983 Jul 1;158(1):252-7. PubMed PMID: 6190980; PubMed Central PMCID: PMC2187072.7: Nolan LL, Berman JD, Giri L. The effect of formycin B on mRNA translation and uptake of purine precursors in Leishmania mexicana. Biochem Int. 1984 Aug;9(2):207-18. PubMed PMID: 6207832.8: Mehta KD, Gupta RS. Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells. Biochem Biophys Res Commun. 1985 Jul 31;130(2):910-7. PubMed PMID: 2992490.9: Plagemann PG, Aran JM, Woffendin C. Na(+)-dependent, active and Na(+)-independent, facilitated transport of formycin B in mouse spleen lymphocytes. Biochim Biophys Acta. 1990 Feb 16;1022(1):93-102. PubMed PMID: 2302407.10: Croft SL, Neal RA. The effect of allopurinol ribonucleoside and formycin B on Trypanosoma cruzi infections in mice. Trans R Soc Trop Med Hyg. 1985;79(4):517-8. PubMed PMID: 3936241.1

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