13877-76-4|Formycin B|3-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one|-范德生物科技公司

Formycin B

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names：
3-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS号：
13877-76-4
MDL Number：
MF(分子式)： C10H12N4O5 MW(分子量)： 268.22
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Formycin B
英文别名	Formycin B; Laurusin; Ohyamycin; NSC 106486; NSC-106486; NSC106486;
CAS号	13877-76-4
Inchi	InChI=1S/C10H12N4O5/c15-1-3-7(16)8(17)9(19-3)5-4-6(14-13-5)10(18)12-2-11-4/h2-3,7-9,15-17H,1H2,(H,13,14)(H,11,12,18)/t3-,7-,8-,9+/m1/s1
InchiKey	MTCJZZBQNCXKAP-KSYZLYKTSA-N
分子式 Formula	C10H12N4O5
分子量 Molecular Weight	268.22
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Formycin B(CAS:13877-76-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Formycin B is a model nucleoside analogue.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wu X, Hui AC, Giacomini KM. Formycin B elimination from the cerebrospinal fluid of the rat. Pharm Res. 1993 Apr;10(4):611-5. PubMed PMID: 8483848.

[2]Borgland SL, Parkinson FE. Uptake and release of [3H]formycin B via sodium-dependent nucleoside transporters in mouse leukemic L1210/MA27.1 cells. J Pharmacol Exp Ther. 1997 Apr;281(1):347-53. PubMed PMID: 9103516.

[3] Burke T, Lee S, Ferguson PJ, Hammond JR. Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. J Pharmacol Exp Ther. 1998 Sep;286(3):1333-40. PubMed PMID: 9732397.

[4] Robinson N, Kaur K, Emmett K, Iovannisci DM, Ullman B. Biochemical genetic analysis of formycin B action in Leishmania donovani. J Biol Chem. 1984 Jun 25;259(12):7637-43. PubMed PMID: 6203896.

[5] Spector T, Jones TE, LaFon SW, Nelson DJ, Berens RL, Marr JJ. Monophosphates of formycin B and allopurinol riboside. Interactions with leishmanial and mammalian succino-AMP synthetase and GMP reductase. Biochem Pharmacol. 1984 May 15;33(10):1611-7. PubMed PMID: 6732835.

6: Berman JD, Rainey P, Santi DV. Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages. J Exp Med. 1983 Jul 1;158(1):252-7. PubMed PMID: 6190980; PubMed Central PMCID: PMC2187072.7: Nolan LL, Berman JD, Giri L. The effect of formycin B on mRNA translation and uptake of purine precursors in Leishmania mexicana. Biochem Int. 1984 Aug;9(2):207-18. PubMed PMID: 6207832.8: Mehta KD, Gupta RS. Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells. Biochem Biophys Res Commun. 1985 Jul 31;130(2):910-7. PubMed PMID: 2992490.9: Plagemann PG, Aran JM, Woffendin C. Na(+)-dependent, active and Na(+)-independent, facilitated transport of formycin B in mouse spleen lymphocytes. Biochim Biophys Acta. 1990 Feb 16;1022(1):93-102. PubMed PMID: 2302407.10: Croft SL, Neal RA. The effect of allopurinol ribonucleoside and formycin B on Trypanosoma cruzi infections in mice. Trans R Soc Trop Med Hyg. 1985;79(4):517-8. PubMed PMID: 3936241.1

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