63516-07-4|Flutropium Bromide|(1R,3s,5S,8r)-8-(2-fluoroethyl)-3-(2-hydroxy-2,2-diphenylacetoxy)-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide|-范德生物科技公司

Flutropium Bromide

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names：
(1R,3s,5S,8r)-8-(2-fluoroethyl)-3-(2-hydroxy-2,2-diphenylacetoxy)-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide
CAS号：
63516-07-4
MDL Number：
MF(分子式)： C24H29BrFNO3 MW(分子量)： 478.4024
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Flutropium Bromide
英文别名	Flutropium Bromide; Flubron; Ba 598; Ba598; Ba-598
CAS号	63516-07-4
SMILES	[H][C@]12C[C@@H](OC(C(C3=CC=CC=C3)(C4=CC=CC=C4)O)=O)C[C@](CC1)([N@+]2(CCF)C)[H].[Br-]
Inchi	InChI=1S/C24H29FNO3.BrH/c1-26(15-14-25)20-12-13-21(26)17-22(16-20)29-23(27)24(28,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,20-22,28H,12-17H2,1H3;1H/q+1;/p-1/t20-,21+,22-,26+;
InchiKey	FNUZASGZEHGWQM-BZUXCDCISA-M
分子式 Formula	C24H29BrFNO3
分子量 Molecular Weight	478.4024
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Flutropium Bromide(CAS:63516-07-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Flutropium Bromide, also known as Flubron, is a competitive antagonist of acetylcholine used to treat asthma and chronic obstructive pulmonary.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Misawa M, Yanaura S, Hosokawa T, Mizuno H, Irinoda K, Takahashi Y, Yoshimura K, Maruyama Y, Sugimoto K, Ohno H, et al. [Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators]. Nihon Yakurigaku Zasshi. 1988 Feb;91(2):97-103. Japanese. PubMed PMID: 2453423.

[2]Mizuno H, Kawabata N, Ohno H, Misawa M. [Effects of flutropium bromide, a new antiasthma drug, with repeated administration on bronchomotor response and hepatic drug metabolizing enzymes]. Nihon Yakurigaku Zasshi. 1989 Jun;93(6):333-40. Japanese. PubMed PMID: 2567689.

[3] Bauer R, Fügner A. Pharmacology of the anticholinergic bronchospasmolytic agent flutropium bromide. Arzneimittelforschung. 1986 Sep;36(9):1348-52. PubMed PMID: 2431695.

[4] Mizuno H, Takahashi Y, Ohno H, Misawa M. [Effects of flutropium bromide, a new anti-asthma drug, alone or in combination with salbutamol, aminophylline and disodium cromoglycate on the acetylcholine induced bronchoconstriction]. Nihon Yakurigaku Zasshi. 1990 Jan;95(1):31-40. Japanese. PubMed PMID: 1968028.

[5] Baba M, Mikami M, Nakamura S, Takizawa J, Kawakami M. [Flutropium bromide was effective in relieving symptoms of lymphangioleiomyomatosis--a case report]. Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1223-7. Japanese. PubMed PMID: 9493450.

6: Banholzer R, Pook KH, Stiasni M. Synthesis of the bronchospasmolytic agent flutropium bromide and of some homologous and configuration isomeric compounds. Arzneimittelforschung. 1986 Aug;36(8):1161-6. PubMed PMID: 3778552.7: Kiel G. Molecular and crystal structure of flutropium bromide. Arzneimittelforschung. 1986 Aug;36(8):1166-8. PubMed PMID: 3778553.8: Ikeda A, Nishimura K, Koyama H, Izumi T. Comparative dose-response study of three anticholinergic agents and fenoterol using a metered dose inhaler in patients with chronic obstructive pulmonary disease. Thorax. 1995 Jan;50(1):62-6. PubMed PMID: 7886652; PubMed Central PMCID: PMC473711.9: Namimatsu A, Go K, Tanimoto H, Okuda M. Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs. Int Arch Allergy Immunol. 1992;97(2):139-45. PubMed PMID: 1374739.10: Shioya T, Kagaya M, Sano M, Itaba M, Shindo T, Miura M. Antimuscarinic effect of tiquizium bromide in vitro and in vivo. Eur J Clin Pharmacol. 1996;50(5):375-80. PubMed PMID: 8839659.

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