66794-74-9|Encainide Hydrochloride|4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride|-范德生物科技公司

Encainide Hydrochloride

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names：
4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride
CAS号：
66794-74-9
MDL Number：
MF(分子式)： C22H29ClN2O2 MW(分子量)： 388.93
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Encainide Hydrochloride
英文别名	Encainide Hydrochloride; Encainide HCl; Enkaid; 66794-74-9; CHEBI59880; Encainide, (+)-Isomer; Encainide, (-)-Isomer; Enkaid MJ 9067; MJ-9067;
CAS号	66794-74-9
SMILES	CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC.Cl
Inchi	InChI=1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H
InchiKey	OJIIZIWOLTYOBS-UHFFFAOYSA-N
分子式 Formula	C22H29ClN2O2
分子量 Molecular Weight	388.93
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Encainide Hydrochloride(CAS:66794-74-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Encainide Hydrochloride is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects. One of the anti-arrhythmia, it blocks voltage-gated sodium channels and slows conduction within the His-Purkinje system and myocardium. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chase SL, Sloskey GE. Encainide hydrochloride and flecainide acetate: twoclass 1c antiarrhythmic agents. Clin Pharm. 1987 Nov;6(11):839-50. Review.Erratum in: Clin Pharm 1988 Apr;7(4):269. PubMed PMID: 3119276.

[2]Treatment of life-threatening ventricular tachycardia with encainidehydrochloride in patients with left ventricular dysfunction. TheEncainide-Ventricular Tachycardia Study Group. Am J Cardiol. 1988 Sep15;62(9):571-5. PubMed PMID: 3137797.

[3] Myerburg RJ, Kessler KM, Cox MM, Huikuri H, Terracall E, Interian A Jr,Fernandez P, Castellanos A. Reversal of proarrhythmic effects of flecainideacetate and encainide hydrochloride by propranolol. Circulation. 1989Dec;80(6):1571-9. PubMed PMID: 2480856.

[4] Horowitz LN. Encainide in lethal ventricular arrhythmias evaluated byelectrophysiologic testing and decrease in symptoms. Am J Cardiol. 1986 Aug29;58(5):83C-86C. Review. PubMed PMID: 3092624.

[5] Morganroth J, Somberg JC, Pool PE, Hsu PH, Lee IK, Durkee J, Salerno DM.Comparative study of encainide and quinidine in the treatment of ventriculararrhythmias. J Am Coll Cardiol. 1986 Jan;7(1):9-16. Erratum in: J Am Coll Cardiol1986 Oct;8(4):992. PubMed PMID: 3079781.

6: Svensson CK, Knowlton PW. Effect of encainide on in vivo drug metabolism inthe rat. Res Commun Chem Pathol Pharmacol. 1987 May;56(2):285-8. PubMed PMID:3110886.7: Bartek MJ, Mayol RF, Boarman MP, Gammans RE, Gallo DG. Analysis of encainideand metabolites in plasma and urine by high-performance liquid chromatography.Ther Drug Monit. 1988;10(4):446-52. PubMed PMID: 3144068.8: Anderson JL, Platia EV, Hallstrom A, Henthorn RW, Buckingham TA, Carlson MD,Carson PE. Interaction of baseline characteristics with the hazard of encainide,flecainide, and moricizine therapy in patients with myocardial infarction. Apossible explanation for increased mortality in the Cardiac ArrhythmiaSuppression Trial (CAST). Circulation. 1994 Dec;90(6):2843-52. PubMed PMID:7994829.9: Case CL, Hewett KW, Gillette PC. Developmental electrophysiology of encainideand its major metabolites on the Purkinje fiber action potential. Biol Neonate.1994;66(6):330-8. PubMed PMID: 7727615.10: Wallace AA, Stupienski RF 3rd, Kothstein T, Gehret JR, Lynch JJ Jr.Demonstration of proarrhythmic activity with the class IC antiarrhythmic agentencainide in a canine model of previous myocardial infarction. J CardiovascPharmacol. 1993 Mar;21(3):397-404. PubMed PMID: 7681500.1

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