3810-80-8|Diphenoxylate HCl|1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester hydrochloride|-范德生物科技公司

Diphenoxylate HCl

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names：
1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester hydrochloride
CAS号：
3810-80-8
MDL Number：
MF(分子式)： C30H33ClN2O2 MW(分子量)： 489.05
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Diphenoxylate HCl
英文别名	Diphenoxylate HCl; Diphenoxylate hydrochloride; R 1132; R-1132; R1132;
CAS号	3810-80-8
SMILES	O=C(OCC)C1(C2=CC=CC=C2)CCN(CCC(C3=CC=CC=C3)(C#N)C4=CC=CC=C4)CC1.[H]Cl
Inchi	InChI=1S/C30H32N2O2.ClH/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;/h3-17H,2,18-23H2,1H3;1H
InchiKey	SHTAFWKOISOCBI-UHFFFAOYSA-N
分子式 Formula	C30H33ClN2O2
分子量 Molecular Weight	489.05
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Diphenoxylate HCl(CAS:3810-80-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Diphenoxylate HCl was discontinued (DEA controlled substance, DEA Schedule V).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhu D, Chen S, Yao SK, Li YM, Chen SX. [Establishment of a canine slow transit constipation model and evalution of defecation, gastrointestinal transit and pathological sections]. Zhonghua Yi Xue Za Zhi. 2018 Jun 12;98(22):1786-179[1]doi: 10.3760/cma.j.issn.0376-2491.2018.22.012. Chinese. PubMed PMID: 29925160.

[2]Wang YB, Ling J, Zhang WZ, Li G, Qiu W, Zheng JH, Zhao XH. Effect of bisacodyl on rats with slow transit constipation. Braz J Med Biol Res. 2018;51(7):e7372. doi: 10.1590/1414-431x20187372. Epub 2018 May 28. PubMed PMID: 29846410; PubMed Central PMCID: PMC5995042.

[3] Zhai X, Lin D, Zhao Y, Yang X. Bacterial Cellulose Relieves Diphenoxylate-Induced Constipation in Rats. J Agric Food Chem. 2018 Apr 25;66(16):4106-4117. doi: 10.1021/acs.jafc.8b00385. Epub 2018 Apr 16. PubMed PMID: 29627986.

[4] Jiang F, Zhou JY, Wu J, Tian F, Zhu XX, Zhu CL, Yang BL, Chen YG. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with Atropine/Diphenoxylate-Induced Slow-Transit Constipation. Evid Based Complement Alternat Med. 2017;2017:4249016. doi: 10.1155/2017/4249016. Epub 2017 Dec 18. PubMed PMID: 29403536; PubMed Central PMCID: PMC5748317.

[5] Tan P, Zhang HZ, Zhang DK, Wu SN, Niu M, Wang JB, Xiao XH. [Quality evaluation of rhubarb dispensing granules based on multi-component simultaneous quantitative analysis and bioassay]. Zhongguo Zhong Yao Za Zhi. 2017 Jul;42(14):2683-2690. doi: 10.19540/j.cnki.cjcmm.2017.0118. Chinese. PubMed PMID: 29098822.

6: Gao F, Sheng HM, Zhang TN, Wu SB, Cao J, Zhou MQ. [Effect of Manual Acupuncture Stimulation of Single Acupoint or Acupoints Combination on Intestinal Movement in Slow Transit Constipation Mice]. Zhen Ci Yan Jiu. 2017 Feb 25;42(1):62-6. Chinese. PubMed PMID: 29072000.7: Gawron AJ, Bielefeldt K. Risk of Pancreatitis Following Treatment of Irritable Bowel Syndrome With Eluxadoline. Clin Gastroenterol Hepatol. 2018 Mar;16(3):378-384.e2. doi: 10.1016/j.cgh.2017.08.006. Epub 2017 Aug 10. PubMed PMID: 28804032.8: Euwema MS, Swanson TJ. Toxicity, Deadly Single Dose Agents. 2017 Oct 6. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK441849/ PubMed PMID: 28722879.9: Luo D, Qu C, Zhang Z, Xie J, Xu L, Yang H, Li C, Lin G, Wang H, Su Z. Granularity and Laxative Effect of Ultrafine Powder of Dendrobium officinale. J Med Food. 2017 Feb;20(2):180-188. doi: 10.1089/jmf.2016.3827. PubMed PMID: 28146409.10: Ling J, Zhang W, Xu B, Qiu W, Wang Y. [Experimental study of Bisacodyl in the treatment of slow transit constipation model rats]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016 Dec 25;19(12):1365-1369. Chinese. PubMed PMID: 28000192.1

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