52423-28-6|Debromoaplysiatoxin|(1R,4R,13R,14S)-13-hydroxy-9-(1-hydroxyethyl)-3-(5-(3-hydroxyphenyl)-5-methoxypentan-2-yl)-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione|-范德生物科技公司

Debromoaplysiatoxin

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names：
(1R,4R,13R,14S)-13-hydroxy-9-(1-hydroxyethyl)-3-(5-(3-hydroxyphenyl)-5-methoxypentan-2-yl)-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione
CAS号：
52423-28-6
MDL Number：
MF(分子式)： C32H48O10 MW(分子量)： 592.726
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Debromoaplysiatoxin
英文别名	Debromoaplysiatoxin; Aplysiatoxin, 17-debromo-; G-2408; NSC 271679.
CAS号	52423-28-6
SMILES	C[C@H]1CC([C@]23CC([C@H](C(O2)C(C)CCC(c4cccc(c4)O)OC)C)OC(=O)CC(OC(=O)C[C@]1(O3)O)C(C)O)(C)C
Inchi	InChI=1S/C32H48O10/c1-18(11-12-24(38-7)22-9-8-10-23(34)13-22)29-20(3)26-16-32(41-29)30(5,6)15-19(2)31(37,42-32)17-28(36)39-25(21(4)33)14-27(35)40-26/h8-10,13,18-21,24-26,29,33-34,37H,11-12,14-17H2,1-7H3/t18?,19-,20+,21?,24?,25?,26?,29?,31+,32+/m0/s1
InchiKey	REAZZDPREXHWNV-FNYQTHNFSA-N
分子式 Formula	C32H48O10
分子量 Molecular Weight	592.726
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Debromoaplysiatoxin(CAS:52423-28-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Debromoaplysiatoxin is a toxic agent produced by the blue-green alga Lyngbya majuscula. This alga lives in marine waters and causes seaweed dermatitis. Furthermore, it is a tumor promoter which has an anti-proliferative activity against various cancer cell lines in mice.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Richard K, Williams DE, de Silva ED, Brockman MA, Brumme ZL, Andersen RJ, Tietjen I. Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products. Viruses. 2018 Jun 27;10(7). pii: E348. doi: 10.3390/v10070348. PubMed PMID: 29954099; PubMed Central PMCID: PMC6071113.

[2]Han BN, Liang TT, Keen LJ, Fan TT, Zhang XD, Xu L, Zhao Q, Wang SP, Lin HW. Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K(+) Channel Inhibition Activity. Org Lett. 2018 Feb 2;20(3):578-581. doi: 10.1021/acs.orglett.7b03672. Epub 2018 Jan 18. PubMed PMID: 29345130.

[3] Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem Biophys Res Commun. 2018 Jan 1;495(1):438-445. doi: 10.1016/j.bbrc.2017.11.052. Epub 2017 Nov 9. PubMed PMID: 29129688.

[4] Puschner B, Bautista AC, Wong C. Debromoaplysiatoxin as the Causative Agent of Dermatitis in a Dog after Exposure to Freshwater in California. Front Vet Sci. 2017 Apr 6;

[5]50. doi: 10.3389/fvets.2017.00050. eCollection 2017. PubMed PMID: 28428958; PubMed Central PMCID: PMC5382154.

5: Kikumori M, Yanagita RC, Tokuda H, Suenaga K, Nagai H, Irie K. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead. Biosci Biotechnol Biochem. 2016;80(2):221-31. doi: 10.1080/09168451.2015.1091718. Epub 2015 Oct 9. PubMed PMID: 26452398.

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