32695-27-5|Dapsone hydroxylamine|4-Amino-4'-hydroxylaminodiphenylsulfone|-范德生物科技公司

Dapsone hydroxylamine

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names：
4-Amino-4'-hydroxylaminodiphenylsulfone
CAS号：
32695-27-5
MDL Number：
MF(分子式)： C12H12N2O3S MW(分子量)： 264.299
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Dapsone hydroxylamine
英文别名	Dapsone hydroxylamine; Dds-noh; HADS; N-Hydroxydapsone;
CAS号	32695-27-5
SMILES	O=S(C1=CC=C(N)C=C1)(C2=CC=C(NO)C=C2)=O
Inchi	InChI=1S/C12H12N2O3S/c13-9-1-5-11(6-2-9)18(16,17)12-7-3-10(14-15)4-8-12/h1-8,14-15H,13H2
InchiKey	IYDSJDWESCGRKW-UHFFFAOYSA-N
分子式 Formula	C12H12N2O3S
分子量 Molecular Weight	264.299
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dapsone hydroxylamine(CAS:32695-27-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dapsone hydroxylamine is the hydroxylamine derivative of the antibacterial dapspone (sc-203023), which is most commonly used as part of a multidrug therapy for the treatment of leprosy and as propchylaxis against pneumocystis pneumonia (PCP) in HIV patients. Dapsone hydroxylamine is a toxic metabolite that is responsible for the hemolytic anemia seen in patients following dapsone therapy.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Andrisani A, Donà G, Sabbadin C, Dall'Acqua S, Tibaldi E, Roveri A, Bosello Travain V, Brunati AM, Ambrosini G, Ragazzi E, Armanini D, Bordin L. Dapsone hydroxylamine-mediated alterations in human red blood cells from endometriotic patients. Gynecol Endocrinol. 2017 Dec;33(12):928-932. doi: 10.1080/09513590.2017.1332177. Epub 2017 May 30. PubMed PMID: 28557604.

[2]Jarratt MT, Jones TM, Chang-Lin JE, Tong W, Berk DR, Lin V, Kaoukhov A. Safety and Pharmacokinetics of Once-Daily Dapsone Gel, 7.5% in Patients With Moderate Acne Vulgaris. J Drugs Dermatol. 2016 Oct 1;15(10):1250-1259. PubMed PMID: 27741344.

[3] Albuquerque RV, Malcher NS, Amado LL, Coleman MD, Dos Santos DC, Borges RS, Valente SA, Valente VC, Monteiro MC. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10(8):e0134768. doi: 10.1371/journal.pone.0134768. eCollection 2015. PubMed PMID: 26284371; PubMed Central PMCID: PMC4540410.

[4] Bordin L, Fiore C, Zen F, Coleman MD, Ragazzi E, Clari G. Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding. Br J Pharmacol. 2010 Nov;161(5):1186-99. doi: 10.1111/j.1476-5381.2010.00962.x. PubMed PMID: 20662842; PubMed Central PMCID: PMC2998697.

[5] Veggi LM, Pretto L, Ochoa EJ, Catania VA, Luquita MG, Taborda DR, Sánchez Pozzi EJ, Ikushiro S, Coleman MD, Roma MG, Mottino AD. Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver. Life Sci. 2008 Aug 1;83(5-6):155-63. doi: 10.1016/j.lfs.2008.05.016. Epub 2008 Jun 18. PubMed PMID: 18602405.

6: Thiboutot DM, Willmer J, Sharata H, Halder R, Garrett S. Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris. Clin Pharmacokinet. 2007;46(8):697-712. PubMed PMID: 17655376.7: Roychowdhury S, Cram AE, Aly A, Svensson CK. Detection of haptenated proteins in organotypic human skin explant cultures exposed to dapsone. Drug Metab Dispos. 2007 Sep;35(9):1463-5. Epub 2007 Jun 6. PubMed PMID: 17553916.8: Roychowdhury S, Vyas PM, Svensson CK. Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells. Drug Metab Dispos. 2007 Apr;35(4):676-81. Epub 2007 Jan 12. PubMed PMID: 17220235.9: McMillan DC, Powell CL, Bowman ZS, Morrow JD, Jollow DJ. Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents. Toxicol Sci. 2005 Nov;88(1):274-83. Epub 2005 Aug 17. PubMed PMID: 16107547.10: Clement B, Behrens D, Amschler J, Matschke K, Wolf S, Havemeyer A. Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Life Sci. 2005 May 27;77(2):205-19. Epub 2005 Feb 8. PubMed PMID: 15862605.1

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