380382-38-7|DA-7867|Acetamide, N-(((5S)-3-(3-fluoro-4-(6-(1-methyl-1H-tetrazol-5-yl)-3-pyridinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-|-范德生物科技公司

DA-7867

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names：
Acetamide, N-(((5S)-3-(3-fluoro-4-(6-(1-methyl-1H-tetrazol-5-yl)-3-pyridinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-
CAS号：
380382-38-7
MDL Number：
MF(分子式)： C19H18FN7O3 MW(分子量)： 411.4
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	DA-7867
英文别名	DA-7867; DA 7867; DA7867; UNII-491MT9GU8K;
CAS号	380382-38-7
SMILES	CC(NC[C@H]1CN(C2=CC=C(C3=CC=C(C4=NN=NN4C)N=C3)C(F)=C2)C(O1)=O)=O
Inchi	InChI=1S/C19H18FN7O3/c1-11(28)21-9-14-10-27(19(29)30-14)13-4-5-15(16(20)7-13)12-3-6-17(22-8-12)18-23-24-25-26(18)2/h3-8,14H,9-10H2,1-2H3,(H,21,28)/t14-/m0/s1
InchiKey	XLLXHGCGAQJLLK-AWEZNQCLSA-N
分子式 Formula	C19H18FN7O3
分子量 Molecular Weight	411.4
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DA-7867(CAS:380382-38-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DA-7867 is a novel oxazolidinone. In vitro activities of DA-7867 were compared to those of linezolid and commonly used antimicrobials. DA-7867 had the lowest MIC for 90% of the aerobic gram-positive bacterial strains tested,
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Vera-Cabrera L, Castro-Garza J, Rendon A, Ocampo-Candiani J, Welsh O, Choi SH, Blackwood K, Molina-Torres C. In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867. Antimicrob Agents Chemother. 2005 Oct;49(10):4351-3. PubMed PMID: 16189119; PubMed Central PMCID: PMC1251498.

[2]Yong D, Yum JH, Lee K, Chong Y, Choi SH, Rhee JK. In vitro activities of DA-7867, a novel oxazolidinone, against recent clinical isolates of aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 2004 Jan;48(1):352-7. Erratum in: Antimicrob Agents Chemother. 2004 May;48(5):1918. PubMed PMID: 14693566; PubMed Central PMCID: PMC310204.

[3] Vera-Cabrera L, Brown-Elliott BA, Wallace RJ Jr, Ocampo-Candiani J, Welsh O, Choi SH, Molina-Torres CA. In vitro activities of the novel oxazolidinones DA-7867 and DA-7157 against rapidly and slowly growing mycobacteria. Antimicrob Agents Chemother. 2006 Dec;50(12):4027-9. Epub 2006 Oct 2. PubMed PMID: 17015632; PubMed Central PMCID: PMC1693997.

[4] Vera-Cabrera L, Daw-Garza A, Said-Fernández S, Lozano-Garza HG, de Torres NW, Rocha NC, Ocampo-Candiani J, Choi SH, Welsh O. Therapeutic effect of a novel oxazolidinone, DA-7867, in BALB/c mice infected with Nocardia brasiliensis. PLoS Negl Trop Dis. 2008 Sep 10;2(9):e289. doi: 10.1371/journal.pntd.0000289. PubMed PMID: 18820738; PubMed Central PMCID: PMC2553479.

[5] Yoon EJ, Jo YW, Choi SH, Lee TH, Rhee JK, Yoo M, Shim MJ, Choi EC. In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria. Antimicrob Agents Chemother. 2005 Jun;49(6):2498-500. PubMed PMID: 15917554; PubMed Central PMCID: PMC1140508.

6: Ji HY, Lee HW, Chang SG, Lee JJ, Rhee JK, Kim WB, Lee HS. Liquid chromatography-tandem mass spectrometry for the determination of a new oxazolidinone antibiotic DA-7867 in human plasma. Biomed Chromatogr. 2004 Mar;18(2):86-9. PubMed PMID: 15039959.7: Bae SK, Kwon JW, Kim WB, Lee I, Lee MG. Effects of acute renal failure on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats. Biopharm Drug Dispos. 2006 Jan;27(1):29-37. PubMed PMID: 16302289.8: Bae SK, Lee SJ, Kwon JW, Kim WB, Lee MG. Effects of protein-calorie malnutrition on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats. J Pharm Pharmacol. 2004 May;56(5):635-42. PubMed PMID: 15142341.9: Bae SK, Chung WS, Kim EJ, Rhee JK, Kwon JW, Kim WB, Lee MG. Pharmacokinetics, blood partition and protein binding of DA-7867, a new oxazolidinone. Biopharm Drug Dispos. 2004 Apr;25(3):127-35. PubMed PMID: 15083501.10: Bae SK, Kim YC, Lee JK, Kwon JW, Yoo M, Lee I, Lee MG. Effects of water deprivation for 72 hours on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats. Biopharm Drug Dispos. 2006 Apr;27(3):147-56. PubMed PMID: 16408258.1

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