134381-30-9|Conagenin|(S)-2-((2R,3S,4R)-2,4-dihydroxy-3-methylpentanamido)-3-hydroxy-2-methylpropanoic acid|-范德生物科技公司

Conagenin

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names：
(S)-2-((2R,3S,4R)-2,4-dihydroxy-3-methylpentanamido)-3-hydroxy-2-methylpropanoic acid
CAS号：
134381-30-9
MDL Number：
MF(分子式)： C10H19NO6 MW(分子量)： 249.26
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Conagenin
英文别名	Conagenin;
CAS号	134381-30-9
SMILES	OC[C@](C(O)=O)(C)NC([C@@H]([C@@H](C)[C@@H](C)O)O)=O
Inchi	InChI=1S/C10H19NO6/c1-5(6(2)13)7(14)8(15)11-10(3,4-12)9(16)17/h5-7,12-14H,4H2,1-3H3,(H,11,15)(H,16,17)/t5-,6+,7+,10-/m0/s1
InchiKey	GLESHRYLRAOJPS-DHCFDGJBSA-N
分子式 Formula	C10H19NO6
分子量 Molecular Weight	249.26
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Conagenin(CAS:134381-30-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Conagenin is a low molecular weight immunomodulator produced by Streptomyces roseosporus.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jiao XZ, Wang LP, Xiao Q, Xie P, Liang XT. Total synthesis of (+)-conagenin. J Asian Nat Prod Res. 2009;11(3):274-80. doi: 10.1080/10286020902828369. PubMed PMID: 19408153.

[2]Kawatsu M, Yamashita T, Ishizuka M, Takeuchi T. Effect of conagenin on thrombocytopenia induced by antitumor agents in mice. J Antibiot (Tokyo). 1994 Oct;47(10):1123-9. PubMed PMID: 7961162.

[3] Hamada M, Yamamoto S, Moriguchi S, Kishino Y. Phagocytosis of alveolar macrophages after conagenin injection to rats. J Antibiot (Tokyo). 2001 Apr;54(4):349-53. PubMed PMID: 11426659.

[4] Kawatsu M, Yamashita T, Osono M, Ishizuka M, Takeuchi T. T cell activation by conagenin in mice. J Antibiot (Tokyo). 1993 Nov;46(11):1687-91. PubMed PMID: 8270490.

[5] Matsukawa Y, Isobe M, Kotsuki H, Ichikawa Y. Synthesis of (+)-conagenin. J Org Chem. 2005 Jun 24;70(13):5339-41. PubMed PMID: 15960545.

6: Yamashita T, Iijima M, Nakamura H, Isshiki K, Naganawa H, Hattori S, Hamada M, Ishizuka M, Takeuchi T, Iitaka Y. Conagenin, a low molecular weight immunomodulator produced by Streptomyces roseosporus. J Antibiot (Tokyo). 1991 May;44(5):557-9. PubMed PMID: 1905708.7: Kawatsu M, Yamashita T, Ishizuka M, Takeuchi T. Improvement of efficacy of antitumor agents by conagenin. J Antibiot (Tokyo). 1995 Mar;48(3):222-5. PubMed PMID: 7730156.8: Hamada M, Sonotake E, Yamamoto S, Moriguchi S. Conagenin derived from Streptomyces roseosporus enhances macrophage functions. J Antibiot (Tokyo). 1999 Jun;52(6):548-51. PubMed PMID: 10470679.9: Kawatsu M, Yamashita T, Ishizuka M, Takeuchi T. Modulation by conagenin of inflammatory mediator productions in mice given 5-fluorouracil. Anticancer Res. 1997 Mar-Apr;17(2A):917-22. PubMed PMID: 9137428.10: Kawatsu M, Yamashita T, Osono M, Masuda T, Ishizuka M, Takeuchi T. Effect of conagenin in tumor bearing mice. Antitumor activity, generation of effector cells and cytokine production. J Antibiot (Tokyo). 1993 Nov;46(11):1692-8. PubMed PMID: 8270491.1

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