1214994-13-4|AS1069562|(S)-2-(((1H-inden-7-yl)oxy)methyl)morpholine benzenesulfonate|-范德生物科技公司

AS1069562

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names：
(S)-2-(((1H-inden-7-yl)oxy)methyl)morpholine benzenesulfonate
CAS号：
1214994-13-4
MDL Number：
MF(分子式)： C20H23NO5S MW(分子量)： 389.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AS1069562
英文别名	AS1069562; AS-1069562; AS 1069562;
CAS号	1214994-13-4
SMILES	O=S(C1=CC=CC=C1)(O)=O.C2(C=CC3)=C3C(OC[C@H]4OCCNC4)=CC=C2
Inchi	InChI=1S/C14H17NO2.C6H6O3S/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12;7-10(8,9)6-4-2-1-3-5-6/h1-4,6,12,15H,5,7-10H2;1-5H,(H,7,8,9)/t12-;/m0./s1
InchiKey	HLSBLOLRAXOIFW-YDALLXLXSA-N
分子式 Formula	C20H23NO5S
分子量 Molecular Weight	389.46
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AS1069562(CAS:1214994-13-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AS1069562 is an inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. It acts by significantly restoring decreased insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Murai N, Fushiki H, Honda S, Murakami Y, Iwashita A, Irie M, Tamura S, Nagakura Y, Aoki T. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. Neuroscience. 2015 Mar 19;289:262-9. doi: 10.1016/j.neuroscience.2014.12.065. Epub 2015 Jan 13. PubMed PMID: 25595980.

[2]Murai N, Takeshita N, Nishigaki F, Irie M, Tamura S, Aoki T, Matsuoka N. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain. Neurol Res. 2015 Jun;37(6):525-30. doi: 10.1179/1743132815Y.0000000007. Epub 2015 Jan 16. PubMed PMID: 25591424.

[3] Murai N, Tsukamoto M, Tamura S, Aoki T, Matsuoka N. Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. Eur J Pharmacol. 2014 Jun 15;73

3:54-61. doi: 10.1016/j.ejphar.2014.03.038. Epub 2014 Apr 1. PubMed PMID: 24704374.

[5] Murai N, Aoki T, Tamura S, Sekizawa T, Kakimoto S, Tsukamoto M, Oe T, Enomoto R, Hamakawa N, Matsuoka N. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. J Pharmacol Exp Ther. 2014 Mar;348(3):372-82. doi: 10.1124/jpet.113.208686. Epub 2013 Dec 12. PubMed PMID: 24338505.

5: Murai N, Aoki T, Tamura S, Yamamoto H, Hamakawa N, Matsuoka N. AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy. Neuropharmacology. 2014 Apr;79:10-6. doi: 10.1016/j.neuropharm.2013.10.030. Epub 2013 Nov 6. PubMed PMID: 24211301.

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