4298-10-6|Ara-fluorocytosine|1-beta-D-Arabinofuranosyl-5-fluorocytosine|-范德生物科技公司

Ara-fluorocytosine

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names：
1-beta-D-Arabinofuranosyl-5-fluorocytosine
CAS号：
4298-10-6
MDL Number：
MF(分子式)： C9H12FN3O5 MW(分子量)： 261.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Ara-fluorocytosine
英文别名	Ara-fluorocytosine; NSC 529180; NSC-529180; NSC529180
CAS号	4298-10-6
SMILES	O=C1N([C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O)C=C(F)C(N)=N1
Inchi	InChI=1S/C9H12FN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17)/t4-,5-,6+,8-/m1/s1
InchiKey	STRZQWQNZQMHQR-MNCSTQPFSA-N
分子式 Formula	C9H12FN3O5
分子量 Molecular Weight	261.21
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ara-fluorocytosine(CAS:4298-10-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ara-fluorocytosine is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Siddiqui MA, Driscoll JS, Marquez VE, Roth JS, Shirasaka T, Mitsuya H, Barchi JJ Jr, Kelley JA. Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines. J Med Chem. 1992 Jun 12;35(12):2195-20[1]PubMed PMID: 1351945.

[2]Thaler M, Bacher J, O'Leary T, Pizzo PA. Evaluation of single-drug and combination antifungal therapy in an experimental model of candidiasis in rabbits with prolonged neutropenia. J Infect Dis. 1988 Jul;158(1):80-8. PubMed PMID: 3392423.

[3] Snyder RD, van Houten B, Regan JD. The inhibition of ultraviolet radiation-induced DNA repair in human diploid fibroblasts by arabinofuranosyl nucleosides. Chem Biol Interact. 1984 Jun;50(1):1-14. PubMed PMID: 6733802.

[4] Mertelsmann R, Drapkin RL, Gee TS, Kempin S, Passe S, Thaler HT, Arlin Z, Dowling M, Dufour P, McKenzie S, To L, Comacho E, Oettgen HF, Burchenal JH, Clarkson B. Treatment of acute nonlymphocytic leukemia in adults: response to 2,2-anhydro-1-B-D-arabinofuranosyl-5-fluorocytosine and thioguanine on the L-12 protocol. Cancer. 1981 Nov 15;48(10):2136-42. PubMed PMID: 6170414.

[5] Watanabe KA, Reichman U, Chu CK, Hollenberg DH, Fox JJ. Nucleosides. 116. 1-(beta-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides. J Med Chem. 1980 Oct;23(10):1088-94. PubMed PMID: 7420353.

6: Brugarolas A, Buesa JM, Lacave AJ, Gracia Marco M, Valle Pereda M. Phase I and II clinical study of anhydro-ara-5-fluorocytosine (AAFC) and ICRF-159 combination in adenocarcinoma of digestive origin. Cancer Clin Trials. 1978 Winter;1(4):289-95. PubMed PMID: 93030.7: Kreis W, Woodcock TM, Meyers MB, Carlevarini LA, Krakoff IH. Physiologic disposition of cytosine arabinoside and its derivatives in man. Cancer Treat Rep. 1977 Jul;61(4):723-6. PubMed PMID: 195729.8: Cook AF. Fluorinated Pyrimidine nucleosides. 1. Synthesis of a nitrogen analogue of the antitumor agent 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine hydrochloride. J Med Chem. 1977 Mar;20(3):344-8. PubMed PMID: 66315.9: Basler GA, Shapiro WR. Comparison of 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine and cytosine arabinoside in the treatment of murine brain tumor. Cancer Treat Rep. 1976 Jul;60(7):875-9. PubMed PMID: 64295.10: Schneyer CA, Galbraith WM. Evaluation of sialogogic action of cyclocytidine (NSC-145668) and anhydro-ara-5-fluorocytidine (NSC-166641). Cancer Chemother Rep. 1975 Sep-Oct;59(5):1019. PubMed PMID: 1203892.1

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