70236-51-0|ADS-J1|2,7-Naphthalenedisulfonic acid, 4-hydroxy-5-(2-(4-((4-((5-hydroxy-6-(2-(2-methoxy-5-sulfophenyl)diazenyl)-7-sulfo-2-naphthalenyl)amino)-6-(phenylamino)-1,3,5-triazin-2-yl)amino)-5-methoxy-2-methylphenyl)diazenyl)-, sodium salt (14)|-范德生物科技公司

ADS-J1

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names：
2,7-Naphthalenedisulfonic acid, 4-hydroxy-5-(2-(4-((4-((5-hydroxy-6-(2-(2-methoxy-5-sulfophenyl)diazenyl)-7-sulfo-2-naphthalenyl)amino)-6-(phenylamino)-1,3,5-triazin-2-yl)amino)-5-methoxy-2-methylphenyl)diazenyl)-, sodium salt (14)
CAS号：
70236-51-0
MDL Number：
MF(分子式)： C44H32N10Na4O16S4 MW(分子量)： 1176.99
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ADS-J1
英文别名	ADS-J1, ADSJ1, ADS J1
CAS号	70236-51-0
Inchi	1S/C44H36N10O16S4.4Na/c1-22-13-32(37(70-3)21-31(22)51-53-34-19-28(72(60,61)62)15-24-16-29(73(63,64)65)20-35(55)39(24)34)47-44-49-42(45-25-7-5-4-6-8-25)48-43(50-44)46-26-9-11-30-23(14-26)17-38(74(66,67)68)40(41(30)56)54-52-33-18-27(71(57,58)59)10-12-36(33)69-2;;;;/h4-21,55-56H,1-3H3,(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H3,45,46,47,48,49,50);;;;/q;4*+1/p-4/b53-51+,54-52+;;;;
InchiKey	ALPKFOALTCELEH-XHRANVDRSA-J
分子式 Formula	C44H32N10Na4O16S4
分子量 Molecular Weight	1176.99
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ADS-J1(CAS:70236-51-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ADS-J1 is an HIV-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, may remarkably enhance HIV-1 sexual transmission and are potential targets for the development of an effective microbicide.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
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备注

[1]Li J, Yang Z, Liu H, Qiu M, Zhang T, Li W, Li Z, Qi T, Qiu Y, Li L, Zhou X, Liu S, Tan S. ADS-J1 disaggregates semen-derived amyloid fibrils. Biochem J. 2019 Mar 29;476(6):1021-1035. doi: 10.1042/BCJ20180886. PubMed PMID: 30877194.

[2]Xun T, Li W, Chen J, Yu F, Xu W, Wang Q, Yu R, Li X, Zhou X, Lu L, Jiang S, Li L, Tan S, Liu S. ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection. Antimicrob Agents Chemother. 2015 Sep;59(9):5123-34. doi: 10.1128/AAC.00385-15. Epub 2015 Jun 8. PubMed PMID: 26055369; PubMed Central PMCID: PMC4538458.

[3] Yu F, Lu L, Liu Q, Yu X, Wang L, He E, Zou P, Du L, Sanders RW, Liu S, Jiang S. ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer. Biochim Biophys Acta. 2014 May;1838(5):1296-305. doi: 10.1016/j.bbamem.2013.12.022. Epub 2014 Jan 3. PubMed PMID: 24388952.

[4] Wang H, Qi Z, Guo A, Mao Q, Lu H, An X, Xia C, Li X, Debnath AK, Wu S, Liu S, Jiang S. ADS-J1 inhibits human immunodeficiency virus type 1 entry by interacting with the gp41 pocket region and blocking fusion-active gp41 core formation. Antimicrob Agents Chemother. 2009 Dec;53(12):4987-98. doi: 10.1128/AAC.00670-09. Epub 2009 Sep 28. PubMed PMID: 19786602; PubMed Central PMCID: PMC2786362.

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