70236-51-0|ADS-J1|2,7-Naphthalenedisulfonic acid, 4-hydroxy-5-(2-(4-((4-((5-hydroxy-6-(2-(2-methoxy-5-sulfophenyl)diazenyl)-7-sulfo-2-naphthalenyl)amino)-6-(phenylamino)-1,3,5-triazin-2-yl)amino)-5-methoxy-2-methylphenyl)diazenyl)-, sodium salt (14)|-范德生物科技公司

ADS-J1

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names：
2,7-Naphthalenedisulfonic acid, 4-hydroxy-5-(2-(4-((4-((5-hydroxy-6-(2-(2-methoxy-5-sulfophenyl)diazenyl)-7-sulfo-2-naphthalenyl)amino)-6-(phenylamino)-1,3,5-triazin-2-yl)amino)-5-methoxy-2-methylphenyl)diazenyl)-, sodium salt (14)
CAS号：
70236-51-0
MDL Number：
MF(分子式)： C44H32N10Na4O16S4 MW(分子量)： 1176.99
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ADS-J1
英文别名	ADS-J1, ADSJ1, ADS J1
CAS号	70236-51-0
SMILES	[Na+].[Na+].[Na+].[Na+].c1c(cc(c2c(cc(cc12)S(=O)(=O)[O-])\N=N\c1c(cc(c(c1)OC)Nc1nc(nc(n1)Nc1cc2cc(c(c(c2cc1)O)\N=N\c1c(ccc(c1)S(=O)(=O)[O-])OC)S(=O)(=O)[O-])Nc1ccccc1)C)O)S(=O)(=O)[O-]
Inchi	1S/C44H36N10O16S4.4Na/c1-22-13-32(37(70-3)21-31(22)51-53-34-19-28(72(60,61)62)15-24-16-29(73(63,64)65)20-35(55)39(24)34)47-44-49-42(45-25-7-5-4-6-8-25)48-43(50-44)46-26-9-11-30-23(14-26)17-38(74(66,67)68)40(41(30)56)54-52-33-18-27(71(57,58)59)10-12-36(33)69-2;;;;/h4-21,55-56H,1-3H3,(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H3,45,46,47,48,49,50);;;;/q;4*+1/p-4/b53-51+,54-52+;;;;
InchiKey	ALPKFOALTCELEH-XHRANVDRSA-J
分子式 Formula	C44H32N10Na4O16S4
分子量 Molecular Weight	1176.99
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ADS-J1(CAS:70236-51-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ADS-J1 is an HIV-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, may remarkably enhance HIV-1 sexual transmission and are potential targets for the development of an effective microbicide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Li J, Yang Z, Liu H, Qiu M, Zhang T, Li W, Li Z, Qi T, Qiu Y, Li L, Zhou X, Liu S, Tan S. ADS-J1 disaggregates semen-derived amyloid fibrils. Biochem J. 2019 Mar 29;476(6):1021-1035. doi: 10.1042/BCJ20180886. PubMed PMID: 30877194.

[2]Xun T, Li W, Chen J, Yu F, Xu W, Wang Q, Yu R, Li X, Zhou X, Lu L, Jiang S, Li L, Tan S, Liu S. ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection. Antimicrob Agents Chemother. 2015 Sep;59(9):5123-34. doi: 10.1128/AAC.00385-15. Epub 2015 Jun 8. PubMed PMID: 26055369; PubMed Central PMCID: PMC4538458.

[3] Yu F, Lu L, Liu Q, Yu X, Wang L, He E, Zou P, Du L, Sanders RW, Liu S, Jiang S. ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer. Biochim Biophys Acta. 2014 May;1838(5):1296-305. doi: 10.1016/j.bbamem.2013.12.022. Epub 2014 Jan 3. PubMed PMID: 24388952.

[4] Wang H, Qi Z, Guo A, Mao Q, Lu H, An X, Xia C, Li X, Debnath AK, Wu S, Liu S, Jiang S. ADS-J1 inhibits human immunodeficiency virus type 1 entry by interacting with the gp41 pocket region and blocking fusion-active gp41 core formation. Antimicrob Agents Chemother. 2009 Dec;53(12):4987-98. doi: 10.1128/AAC.00670-09. Epub 2009 Sep 28. PubMed PMID: 19786602; PubMed Central PMCID: PMC2786362.

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