913645-39-3|8-Nitro-cGMP|8-Nitroguanosine-3',5'-cyclic monophosphate sodium salt|-范德生物科技公司

8-Nitro-cGMP

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names：
8-Nitroguanosine-3',5'-cyclic monophosphate sodium salt
CAS号：
913645-39-3
MDL Number：
MF(分子式)： C10H10N6NaO9P MW(分子量)： 412.19
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

8-Nitro-cGMP（913645-39-3） is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation.

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中文别名	8-Nitro-cGMP
英文别名	8-NO2-cGMP; 8-Nitro-cGMP; 8 Nitro-cGMP; 8NitrocGMP
CAS号	913645-39-3
Inchi	InChI=1S/C10H11N6O9P.Na/c11-9-13-6-3(7(18)14-9)12-10(16(19)20)15(6)8-4(17)5-2(24-8)1-23-26(21,22)25-5;/h2,4-5,8,17H,1H2,(H,21,22)(H3,11,13,14,18);/q;+1/p-1/t2-,4-,5-,8-;/m1./s1
InchiKey	GNFKAYUNSILMKO-YEOHUATISA-M
分子式 Formula	C10H10N6NaO9P
分子量 Molecular Weight	412.19
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	8-Nitro-cGMP(CAS:913645-39-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H. 8-Nitro-cGMP attenuates context-dependent fear memory in mice. Biochem Biophys Res Commun. 2019 Mar 26;511(1):141-147. doi: 10.1016/j.bbrc.2019.01.138. Epub 2019 Feb 14. PubMed PMID: 30773263.

[2]Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R. Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E(2). In Vitro Cell Dev Biol Anim. 2019 Jan;55(1):45-51. doi: 10.1007/s11626-018-0304-0. Epub 2018 Nov 5. PubMed PMID: 30397855.

[3] Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H. Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2165-2170. doi: 10.1016/j.bbrc.2017.12.088. Epub 2017 Dec 16. PubMed PMID: 29258821.

[4] Kaneko K, Miyamoto Y, Tsukuura R, Sasa K, Akaike T, Fujii S, Yoshimura K, Nagayama K, Hoshino M, Inoue S, Maki K, Baba K, Chikazu D, Kamijo R. 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL. Nitric Oxide. 2018 Jan 30;7

[5]46-51. doi: 10.1016/j.niox.2017.11.006. Epub 2017 Nov 26. PubMed PMID: 29183803.

5: Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H. 8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25. ACS Chem Neurosci. 2018 Feb 21;9(2):217-223. doi: 10.1021/acschemneuro.7b00363. Epub 2017 Nov 10. PubMed PMID: 29110463.

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